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Cytokines, what you need and what we have

Date:2020-12-08 Views:475

Cytokines are small proteins (~5–20 kDa) that are crucial in controlling the growth and activity of other immune system cells and blood cells. Cytokines have been shown to be involved in autocrine, paracrine and endocrine signaling as immunomodulating agents. When released, they signal the immune system to do its job.

 

(Image source: Google)

Cytokine is a general name; other names include chemokines, interferons, interleukins, lymphokines, and tumour necrosis factors, but generally not hormones or growth factors (despite some overlap in the terminology). Cytokines are produced by a broad range of cells, including immune cells like macrophages, B lymphocytes, T lymphocytes and mast cells, as well as endothelial cells, fibroblasts, and various stromal cells; a given cytokine may be produced by more than one type of cell. They act through cell surface receptors and are especially important in the immune system;  It is common for different cell types to secrete the same cytokine or for a single cytokine to act on several different cell types (pleiotropy).

(Image source: Cytokines, Inflammation and Pain)

Cytokines can have either pro- or anti-inflammatory effects, and these effects can be contextual. For inflammation, cytokines can be divided into two categories. One is Pro-inflammatory cytokines, such as IL-1β, IL-6, IL-12, TNF, IFN-γ, etc., which can help activate the tree Dendritic cells, pro-inflammatory macrophages, neutrophils, effector T cells, B cells, etc., promote the occurrence and development of inflammatory reactions; The other type is anti-inflammatory cytokines, such as IL-4, IL-10 , IL-13, TGF-β, etc., can help activate regulatory T cells (Treg), anti-inflammatory macrophages, etc., regulate inflammation, and "neutralize" the effects of pro-inflammatory cytokines.

 

The cytokines provided by Abbkine include interleukin, chemokine, colony stimulating factor (CSF), interferon, transforming growth factor (TGF) and tumor necrosis factor (TNF), which are used in cancer, apoptosis, endocrinology, immunology, neuroscience, protease and stem cell research. These cytokines have been rigorously verified to meet the demand of R&D personnel for high quality, high biological activity and competitive price. The specific product list is as follows:

Preparation method Product name Catalog no Molecular weight
E. coli Human IL-6 protein PRP1012 20.6 kDa
Human TNF-alpha protein PRP1013 17.7 kDa
Human bFGF protein PRP1010 17.3 kDa
Mouse bFGF protein PRP1011 16.4 kDa
Human IFN-gamma protein, His Tag PRP1014 18.0 kDa
Mouse IFN-gamma protein, His Tag PRP1015 16.9 kDa
Human GM-CSF protein PRP1016 14 kDa
Human IL-33 protein PRP1018 18 kDa
Mouse IL-33 protein PRP1118 17.7 kDa
Human IL-1 beta protein PRP1019 17 kDa
Mouse IL-1 beta protein PRP1119 16.9 kDa
Human MCP2 protein, SUMO tag PRP1020 20.3 kDa
Mouse TNF-alpha protein PRP1113 17 kDa
Human IL-2 protein PRP1025 15.5 KD
Mouse LIF protein, C-His tag PRP1126 20.5 KD
Human IL36 alpha protein PRP1027 17 KD
Rat IL-1 beta protein PRP1219 17.4 KD
Human TRAIL protein PRP1028 19.5 KD
Human FGF1/FGF acidic protein PRP1001 15.5 KD
Rat bFGF protein PRP1210 16.2 KD
HEK293 Cells Human GM-CSF protein (Animal-Free) PRP2016 14.5-23.8 kDa
Mouse IL-4 protein (Animal-Free) PRP2117 15-19 kDa
Mouse IL-6 protein, His tag (Animal-Free) PRP2112 21.9 KD
Mouse TGF beta 1 protein, His tag (Animal-Free) PRP1017 16.2 KD