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Human IL36 alpha protein

Human IL36 alpha protein

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Specification

Product name Human IL36 alpha protein
Sequence Amino acid sequence derived from Human IL36 alpha (Q9UHA7) (Lys6-Phe158) was expressed.
Protein length The recombinant Human IL36 alpha consists of 153 amino acids and has a predicted molecular mass of 17 KD.
Preparation method E. coli
Purity >98% as determined by SDS-PAGE
Alternative Interleukin-36 Alpha; FIL1 Epsilon; Interleukin-1 Epsilon; IL-1 Epsilon; Interleukin-1 Family Member 6; IL-1F6; IL36A; FIL1E; IL1E; IL1F6

Product Properties

Formulation Lyophilized from sterile PBS, pH 7.4.
Features & Benefits Endotoxin: < 0.1 EU per µg of the protein as determined by the LAL method.
Molecular weight 17 KD
Usage notes Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human IL36 alpha protein using the buffer we provided not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
Storage instructions Lyophilized Human IL36 alpha protein product should be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Shipping The product is shipped at ambient temperature.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background Human IL36 alpha previously called IL-1F6 and FIL1 epsilon (family of IL-1 member epsilon), is a member of the IL-1 family which includes IL-1b, IL-1a, IL-1ra, IL-18, IL-36ra (IL1F5), IL-36b (IL1F8), IL-36g (IL1F9), IL-37 (IL1F7) and IL-38 (IL-1F10). IL36a is a pro-inflammatory cytokine which plays an important role in innate and adaptive immunity. IL36a is expressed in the immune system and the fetal brain, but not in other tissues or multiple hematopoietic cell lines.IL-36 alpha, beta, and gamma all activate NF-kappa B and MAPK pathways in an IL‑1 Rrp2 dependent manner, and induce production of inflammatory cytokines and chemokines such as CXCL8/IL-8. IL-36 alpha and other family members are overexpressed in psoriatic skin lesions, and transgenic overexpression of IL‑36 alpha in skin keratinocytes produces epidermal hyperplasia.
Gene ID 27179
Alternative Interleukin-36 Alpha; FIL1 Epsilon; Interleukin-1 Epsilon; IL-1 Epsilon; Interleukin-1 Family Member 6; IL-1F6; IL36A; FIL1E; IL1E; IL1F6
Accession Q9UHA7

Image & description

Fig. SDS-PAGE analysis of Human IL36 alpha protein, N-His tag.

Fig. SDS-PAGE analysis of Human IL36 alpha protein, N-His tag.

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