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Human TRAIL protein

Human TRAIL protein

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Specification

Product name Human TRAIL protein
Sequence Amino acid sequence derived from human TRAIL isoform (P50591-1) (Val114-Gly281) was expressed.
Protein length The recombinant human TRAIL consists of 168 amino acids and has a predicted molecular mass of 19.5 KDa.
Preparation method E. coli
Purity >92% as determined by SDS-PAGE
Alternative Tumor Necrosis Factor Ligand Superfamily Member 10; Apo-2 Ligand; Apo-2L; TNF-Related Apoptosis-Inducing Ligand; Protein TRAIL; CD253; TNFSF10; APO2L; TRAIL

Product Properties

Formulation Lyophilized from sterile 20 mM Tris, 150 mM NaCl, pH 8.0.
Features & Benefits Endotoxin: < 1.0 EU per µg of the protein as determined by the LAL method.
Molecular weight 19.5 KD
Usage notes Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human TRAIL protein using the buffer we provided not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
Storage instructions Lyophilized Human TRAIL protein product should be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Shipping The product is shipped at ambient temperature.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background The protein encoded by Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3.
Gene ID 8743
Alternative Tumor Necrosis Factor Ligand Superfamily Member 10; Apo-2 Ligand; Apo-2L; TNF-Related Apoptosis-Inducing Ligand; Protein TRAIL; CD253; TNFSF10; APO2L; TRAIL
Accession P50591

Image & description

Fig. SDS-PAGE analysis of Human TRAIL protein.

Fig. SDS-PAGE analysis of Human TRAIL protein.

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