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Alkaline phosphatase and Bone Metabolism

AKP / ALP is a zinc-containing glycoprotease that can hydrolyze various natural and synthetic phospholipid monoester compounds in an alkaline environment. AKP / ALP is widely distributed in various organs of the human body, mainly the liver. An alkaline phosphatase level test (ALP test) measures the amount of alkaline phosphatase enzyme in your bloodstream. The test requires a simple blood draw and is often a routine part of other blood tests. An ALP test may be performed to determine how well your liver and gallbladder are functioning or to identify problems with your bones. Figure 1: Smart nanoprobes in the detection of ALP(Picture Source: https://pubs.rsc.org ) Bone and liver alkaline phosphatases are the predominant alkaline phosphatase (ALP) isoenzymes in serum…

2021-07-26 61 views

Abbkine mitochondrial respiratory chain complex series detection kits and tricarboxylic acid cycle series detection kits

Some time ago, Abbkine launched a lot of rare treasures with full horsepower, and quickly captured the hearts of a large number of heroes and knights on the rivers and lakes, and received rave reviews. To this end, the editor deliberately shows the members who have recently debuted in the center of the traffic. Type Item No.  Product Name Flow Explosion Series BMU101-EN SuperKine™ West Pico PLUS Chemiluminescent Substrate BMU102-EN SuperKine™ West Femto Maximum Sensitivity Substrate BMU103-EN SuperKine™ Enhanced Antibody Dilution Buffer KTD101-EN Universal Loading Control Antibody Cocktail Mitochondrial respiratory chain complex series KTB1850 CheKine™ Mitochondrial complex I Activity Assay Kit (colorimetric) KTB1860 CheKine™ Mitochondrial complexⅡ Activity Assay Kit (colorimetric) KTB1870 CheKine™ Mitochondrial complex Ⅲ Activity Assay Kit (colorimetric) KTB1880…

2021-07-19 129 views

New arrival |【sRANKL】Recombinant human soluble RANK ligand

【sRANKL】Recombinant human soluble RANK ligand Introduction to sRANKL Tumor necrosis factor ligand superfamily member 11, also known as nuclear factor receptor activator kappa-B ligand, osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, expressed in a variety of cells, including osteogenic Cells, fibroblasts, activated T cells and bone marrow stromal cells can interact with the decoy receptor OPG. TNFSF11 participates in many basic biological processes, such as regulating the interaction between T cells and dendritic cells, regulating T cell-dependent immune responses and enhancing bone resorption in humoral hypercalcemia of malignant tumors. TNFSF11 also enhanced the ability of dendritic cells to stimulate the proliferation of naive T cells. Product information Related product information Product Name Item No. Mouse RANKL protein PRP1114  …

2021-07-02 116 views

New arrival |【FGF21】Recombinant Human Fibroblast Growth Factor 21

【FGF21】Recombinant Human Fibroblast Growth Factor 21 Introduction to FGF21 FGF21 is a member of the Fibroblast Growth Factor (FGFs) family. The proteins of this family have a wide range of mitogenic and cell survival activities, and are involved in a variety of biological processes, such as angiogenesis, wound healing, neurodevelopment, and tumor occurrence and development. Most FGFs (FGF3-8, 10, 15, 17-19, 21-23) have typical signal sequence secreted proteins at the N-terminus. Among them, Fibroblast Growth Factor 21 (FGF 21) is specific in the liver Sexual expression, reducing blood sugar and triacylglycerols through the scope of adipose tissue and pancreas. Glucagon improves the function of pancreatic islet B cells, thereby preventing diet-induced obesity and insulin resistance. In addition, FGF21 has also…

2021-07-02 140 views

New arrival |【Annexin V/ANXA5】Recombinant Human Annexin A5

【Annexin V/ANXA5】Recombinant Human Annexin A5 Introduction to Annexin V Annexin V is a calcium ion-dependent phospholipid binding protein with a molecular weight of 35~36KDa, which can specifically bind to phosphatidylserine PS with high affinity. In normal cells, phosphatidylserine is only distributed on the inner side of the lipid bilayer of the cell membrane. In the early stage of cell apoptosis, the membrane phosphatidylserine (PS) turns from the inner side of the lipid membrane to the outer side. As a phospholipid binding protein, Annexin V has a high affinity with phosphatidylserine. It binds to the cell membrane of cells in the early stage of apoptosis through the phosphatidylserine exposed on the outside of the cell. Therefore, Annexin V is a sensitive…

2021-07-02 108 views

New arrival: Unique recombinant protein

Abbkine’s new day is coming in July. There are 4 new products in this issue, including 3 recombinant protein products  and 1 biochemical test kit, the specific information is as follows: Next, I will focus on introducing 3 recombinant protein products in this issue! Established in 2012, Abbkine always listens to customer needs and continues to develop innovative biological reagent products, hoping to become a key promoter in the fields of life sciences and drug research and development. After unremitting efforts, Abbkine has established a complete protein expression platform, focusing on cultivating professional and excellent technical personnel. It has successively developed hundreds of high-quality recombinant protein products and established a complete set of production, quality control and activity evaluation system.…

2021-07-02 163 views

Four new products join forces, Abbkine gives you unlimited possibilities

Remember in April, Abbkine solemnly launched 4 high-traffic products? Universal internal reference antibody cocktail set, antibody diluent, enhanced/hypersensitive ECL luminescent solution! These 4 products are a set of meticulous and brand-new products launched by Abbkine after months of painstaking research. Once launched, they have received unanimous praise from customers. In order to help everyone better understand the product information, the data of the 4 products are summarized now, let’s take a closer look: KTD101-EN Universal Internal Reference Cocktail Application principle: internal reference of WB experiment needs to consider at least two factors: experimental system and sample to be tested. Due to its relative stability and broad spectrum, internal reference proteins are widely used as internal reference for WB experimental system,…

2021-06-28 153 views

Reactive Oxygen Species and Oxidative Stress

Oxidative stress starts with free radicals which are created as normal byproducts of cell metabolism. Reactive oxygen and nitrogen species (RONS) are produced by several endogenous and exogenous processes, and their negative effects are neutralized by antioxidant defenses. Oxidative stress occurs from the imbalance between RONS production and these antioxidant defenses. Reactive oxygen species (ROS) serve as cell signaling molecules for normal biologic processes which include the superoxide anion, hydrogen peroxide, hydroxyl radical, and single oxygen. Reactive oxygen species (ROS) regulate cellular homeostasis and act as prime modulators of cellular dysfunction contributing to disease pathophysiology. Fig 1: Overview of ROS and Oxidative Stress(Picture Source: https://www.slideshare.net/DilveenOmer/oxidative-stress-141808423) Through years of efforts, Abbkine has developed a series of assay kits to study cell…

2021-06-18 149 views

Essential guidance|Protein ‘Linkine’ Knowledge Class has started, come to learn!

Application background of ‘linkine’ (protein/antibody labeling) technology 1.How to define coupling? Enzymes, biotin, fluorescein, agarose, magnetic beads and other substances that are easy to detect or separate are covalently labeled or conjugated to antibodies, proteins or other small molecular substances using certain techniques. 2.Why is there a ‘linkine’ (protein/antibody labeling) technology? The coupling of antibodies, proteins or other small molecules is a necessary step for many types of biological experiments. such as: In order to detect specific proteins in immunoassays (such as WB/IHC/IF and other immunological experiments), we couple the primary or secondary antibody with enzymes, luciferin, etc.; In cell staining (bioimaging) applications, the reactive dye (fluorescein) is directly combined with the protein (polypeptide) outside or inside the cell to…

2021-06-03 171 views

Metabolism Assay kits, We have all the kinds you need!

Metabolism Assay kits is mainly developed by using the principle of chemical reaction/enzymatic reaction or material structure characteristics to determine material content or enzyme activity in samples. CheKine™ Metabolism Assay kits independently developed by Abbkine Bio have a wide range of applications, including oxidation/antioxidation, stress resistance, glutathione, amino acids, glycolysis, sugar metabolism, fatty acid metabolism, coenzyme I/II, ions, ATP and so on. The types of detected samples include animal and plant tissues, serum, plasma, cells, bacteria, various fluids, etc. The main detection instruments are microplate reader and spectrophotometer. The CheKine™ Metabolism Assay kits of Abbkine adopts more efficient and innovative detection technology and optimized experimental scheme. The kit includes a complete set of reagents and standards required for detection, and…

2021-05-31 236 views