Topic of This Issue: Magical Superoxide anion
Background:
Superoxide ion (O2·−), which is considered both a radical and an anion with the radical sign ( . ) and a charge of −1, is produced by the one-electron reduction of molecular oxygen and is of great significance as a radical species implicated in diverse chemical and biological systems. Superoxide anion is a byproduct of respiration and a crucial component of the immune defense system. It can be generated from two major sources: the mitochondrial respiratory chain and phagocytic nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase). Under normal circumstances, the biological system releases an enzyme, superoxide dismutase (SOD), which specifically maintains the Superoxide anion concentration at an optimal level.
Nevertheless, whe n overproduction of Superoxide anion occurs and/or antioxidant defences are deficient, oxidative stress may develop, damaging important biomolecules and altering their physiological function. For example, Superoxide anion attacks cellular components causing damage to lipids, proteins, and nucleic acids. This can initiate numerous diseases, including cancer, atherosclerosis, rheumatoid arthritis, diabetes, liver damage, sarcopenia, obesity, degenerative diseases that cause urological disorders , fibrous alveoli, bronchopneumonia dysplasia, adult respiratory distress syndrome, Alzheimer's disease and central nervous system disorders.
Product Recommendation:
|
Product name |
Catalog No. |
Product Features |
| CheKine™ Superoxide Dismutases (SOD) Assay Kit | • Determination of SOD enzyme activity in serum, plasma, tissue/cell lysates and other biological fluids.
• Determining SOD activity by WST-8 method, the maximum inhibition percentage can be close to 100%, and it can not be interfered by some common interfering factors. • A broad range linearity: 200-3.13 U/ml. |
|
| CheKine™ Lipid Peroxidation (MDA) Assay kit | • Determination of MDA in serum, plasma, urine, tissue/cell lysates and other biological fluids.
• A broad range linearity: 1-100 µM/L. • Fast and convenient, measuring lipid peroxidation in a wide range of samples. |
|
| CheKine™ Xanthine Oxidase Assay Kit | • Determination of xanthine oxidase activity in serum, plasma, tissue/cell lysates and other biological fluids.
• A broad range linearity: 15.6 -500 mU/mL. |
|
| CheKine™ Superoxide anion Scavenging Capacity Assay Kit | • Determination the Superoxide anion Scavenging ability in various samples, including serum, plasma, tissue/cell lysates and other biological fluids. |
About Abbkine Scientific Co., Ltd.
Abbkine Scientific Co., Ltd. was founded in 2012. Abbkine focuses on the fields of Immunology and Cytology, and is committed to innovating and developing various types of antibodies, proteins, analytical reagents and kits, with a view to becoming a key promoter in the fields of life science research and development, and drug development.
