Review of Related Articles:
Glycogen synthase kinase-3 (GSK-3) is a serine-threonine kinase that has been evolutionarily very conservative.The protein encoded by GSK3β (glycogen synthase kinase 3 beta) is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation.
GSK-3β can also act on many signaling protein structural proteins and transcription factors, and regulate cell differentiation, proliferation, survival and apoptosis. GSK-3β is a key enzyme involved in liver glucose metabolism. It inhibits its activity by phosphorylating GS, reduces liver glucose synthesis, increases blood glucose concentration in the body, is controlled by insulin in the insulin signaling pathway, and participates in liver glucose metabolism.
Polymorphisms in GSK3β have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of GSK3β may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for GSK3β .
The picture is from https://link.springer.com/article/10.1007/s12035-013-8571-y
AbbkineGSK3β Mouse Monoclonal antibody (1A6) helps basic research! Basic information about the product:
|Product name||#CAT||Reactivity||Applications||Dilution ratio||Observed Band(KD)|
|GSK3β Mouse Monoclonal antibody (1A6)||ABM0076||human/mouse/rat||WB/IHC-P||WB (1:1000-1:2000) IHC-P (1:100-1:200)||46 kD|
GSK3β Mouse Monoclonal antibody (1A6) verification results:
|Immunohistochemical analysis of paraffin-embedded Human Breast Carcinoma Tissue using GSK3β Mouse mAb diluted at 1:200.|
|Immunohistochemical analysis of paraffin-embedded Human Stomach Carcinoma Tissue using GSK3β Mouse mAb diluted at 1:200.|
|Western blot analysis of 1) Hela Cell Lysate, 2) 3T3 Cell Lysate, 3) Rat Brain Tissue Lysate using GSK3β Mouse mAb diluted at 1:1000.|