ACTA2 (actin alpha 2) is an actin protein with several aliases including alpha-actin, alpha-actin-2, aortic smooth muscle or alpha smooth muscle actin (α-SMA, SMactin, alpha-SM-actin, ASMA). Actins are a family of globular multi-functional proteins that form microfilaments. ACTA2 is one of 6 different actin isoforms and is involved in the contractile apparatus of smooth muscle. ACTA2 (as with all the actins) is extremely highly conserved and found in nearly all mammals.
In humans, ACTA2 is encoded by the ACTA2 gene located on 10q22-q24. Mutations in this gene cause a variety of vascular diseases, such as thoracic aortic disease, coronary artery disease, stroke, Moyamoya disease, and multisystemic smooth muscle dysfunction syndrome.
ACTA2 (commonly referred to as alpha-smooth muscle actin or α-SMA) is often used as a marker of myofibroblast formation.
Figure: Diverse origins of the myofibroblast—implications for kidney fibrosis (From Nature Reviews)
Abbkine α-SMA Monoclonal Antibody Helps Basic Cancer Research! Basic information about the product:
|Product name||#CAT||Reactivity||Applications||Dilution ratio||Observed Band(KD)|
|α-SMA Monoclonal Antibody||ABM0052||Human/Mouse/ Rat||WB/IF/IHC-P||WB (1:10000-1:100000) IF (1:100-1:200) IHC-P (1:1000-1:2000)||42KD|
Abbkine α-SMA Monoclonal Antibody verification results:
|Western blot analysis of 1) Hela, 2) 3T3, 3) rat brain using α-SMA Monoclonal Antibody.|
|Immunofluorescence analysis of human liver tissue.|
|Immunohistochemical analysis of paraffin-embedded mouse liver tissue|