Human Testican-1 (SPOCK1) ELISA Kit: Decoding the Extracellular Matrix in Cancer and Beyond
SPOCK1: The Proteoglycan at the Intersection of ECM Remodeling and Metastasis
Testican-1 (SPOCK1) is a proteoglycan that plays a dual role in extracellular matrix (ECM) organization and cellular signaling[reference:33]. Its dysregulation has been implicated in cancer metastasis, making it an emerging biomarker for tumor progression and peritoneal dissemination[reference:34].
Abbkine's Human Testican-1 (SPOCK1) ELISA Kit (KTE60335) employs a robust sandwich ELISA format—the gold standard for specific protein quantification in complex biological matrices[reference:35].
Cancer Metastasis Research
SPOCK1 is increasingly recognized as a driver of:
- Peritoneal dissemination — a 3-fold SPOCK1 surge in circulating tumor cells predicts dissemination[reference:36]
- Epithelial-mesenchymal transition (EMT) — SPOCK1 promotes invasive phenotypes
- Tumor microenvironment remodeling — ECM degradation and stromal activation
- Adjuvant therapy decisions — SPOCK1 levels inform treatment stratification[reference:37]
Extracellular Matrix Biology
Beyond cancer, SPOCK1 is essential for:
- ECM organization and maintenance
- Cell-ECM interactions and mechanotransduction
- Tissue development and morphogenesis
- Wound healing and tissue repair
Sample Compatibility
The kit is validated for:
- Serum and plasma[reference:38]
- Cell culture supernatants[reference:39]
- Tissue lysates and other biological fluids[reference:40]
Why Choose KTE60335?
- High sensitivity and excellent specificity for Human SPOCK1[reference:41]
- No significant cross-reactivity with analogues[reference:42]
- Sandwich ELISA format for accurate quantification[reference:43]
- Robust performance in complex biological matrices[reference:44]
📊 Your Research Area?
Cancer Metastasis | Extracellular Matrix | Tumor Biology | Adjuvant Therapy
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