Human SULF2 ELISA Kit: Illuminating the Heparan Sulfate Modification Pathway
SULF2: The Master Regulator of Heparan Sulfate Signaling
Extracellular sulfatase Sulf-2 (SULF2) is an enzyme that exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity[reference:91]. It removes sulfate from the C-6 position of glucosamine within specific subregions of intact heparin and heparan sulfate proteoglycans (HSPGs)[reference:92]. By modifying the sulfation patterns of HSPGs, SULF2 regulates the availability and activity of numerous growth factors, including FGFs, VEGFs, and Wnts.
Abbkine's Human Extracellular Sulfatase Sulf-2 (SULF2) ELISA Kit (KTE60401) offers a sensitive, specific, and reproducible sandwich ELISA designed for accurate measurement of SULF2 in a variety of human biological samples[reference:93].
Cancer Research & Tumor Microenvironment
SULF2 is increasingly recognized as a key player in:
- Tumor progression — SULF2 modifies the tumor microenvironment to promote invasion
- Growth factor signaling — regulating FGF, VEGF, and Wnt pathway activity
- Metastasis — HSPG remodeling facilitates tumor cell dissemination
- Therapeutic resistance — SULF2-mediated signaling adaptation
Developmental Biology & Tissue Homeostasis
Beyond cancer, SULF2 is essential for:
- Embryonic development and morphogenesis
- Tissue repair and regeneration
- Stem cell niche regulation
- Angiogenesis and vascular remodeling
Sample Compatibility & Kit Features
- High sensitivity and excellent specificity for Human SULF2[reference:94]
- No significant cross-reactivity with analogues[reference:95]
- Sandwich ELISA format—the gold standard for protein quantification[reference:96]
- Validated for serum, plasma, cell culture supernatants, and other biological fluids[reference:97]
- Priced at $339 for 48 tests[reference:98]
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Cancer Biology | Developmental Biology | Glycobiology | Tumor Microenvironment
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