The Anti-Histone H3 Mouse Monoclonal Antibody (2D10) is otherwise known as Hist1h3a antibody getting its name from Histone H3, one of the five major histone proteins. Histone H3 is involved in the structuring of chromatin in eukaryotic cells and a major component of nucleosome. Nucleosome wrap and compact DNA limit DNA accessibility to the cellular machineries requiring DNA as a template. Therefore, histones play a pivotal role in the transcription, regulation, DNA replication, repair and chromosomal stability.
The Histone H3 antibody has a human, mouse, rat and yeast reactivity with recombinant protein immunogen and the mouse as host. The monoclonal antibody has Mouse IgG1 isotype with IF, IP, WB applications. The team at Abbkine has suggested starting dilutions of WB 1:2000-5000, IF:1:100-500, IP 1:200, while reiterating that investigators should determine the optimal working dilutions experimentally.
The product is available in liquid solution and has been affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
The product is made for research purpose only and should be used in human or clinical diagnosis. If stored under the right conditions, the antibody can last for as long as a year.
Abbkine Scientific has grown from being a relatively small startup that was established in California in 2012 to become a global provider of scientific research products and tools. The company moved it headquarters to China due to growing demands from Asia Pacific.
Established by a team of marketing experts and scientists, Abbkine Scientific Co. Ltd combines state-of-the-art technology from the United States of America with cost advantages and high quality manufacturing from China to provide innovative solutions and products that are designed to enhance research in life sciences.