EliKine™ Human IL-17 ELISA Kit — Application Scenarios for Inflammation and Autoimmune Research

IL-17: A Key Driver of Inflammation and Autoimmunity

Interleukin 17 (IL-17) , also known as IL-17A or CTLA8, is a proinflammatory cytokine produced by activated T cells, particularly Th17 cells[reference:130]. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases[reference:131]. IL-17 can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO) [reference:132]. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and inflammatory bowel disease[reference:133].

Abbkine's EliKine™ Human IL-17 ELISA Kit (KTE6022) provides researchers with a sensitive, specific, and reliable tool for quantifying this critical proinflammatory cytokine in human samples. With 3 publications citing this kit[reference:134], it's a trusted tool in the research community. Here's how researchers across different fields are putting it to work.

Autoimmune Disease Research: Th17-Mediated Pathology

IL-17 is the signature cytokine of Th17 cells, which are key drivers of autoimmunity. Autoimmune disease researchers use this kit to:

• Quantify IL-17 in autoimmune disease models (rheumatoid arthritis, multiple sclerosis, psoriasis, IBD)
• Monitor Th17 cell activity in autoimmune pathogenesis
• Assess the effects of anti-IL-17 therapies on disease progression
• Study IL-17 as a biomarker of autoimmune disease severity

The sandwich ELISA format delivers quantitative data from serum, plasma, or cell culture supernatants[reference:135].

Inflammation Research: Acute and Chronic Inflammation

IL-17 is a potent proinflammatory cytokine that drives neutrophil recruitment and tissue inflammation. Inflammation researchers leverage this kit to:

• Quantify IL-17 in acute and chronic inflammatory models
• Monitor IL-17 levels in inflammatory disease (sepsis, inflammatory bowel disease)
• Study IL-17's role in inflammatory signaling pathways (NF-κB, MAPK)
• Assess the effects of anti-inflammatory compounds on IL-17 production

High sensitivity (4 pg/mL LOD) ensures detection of even low-level IL-17 in samples[reference:136].

Infectious Disease Research: Host Defense and Immunopathology

IL-17 plays a critical role in host defense against extracellular bacteria and fungi, but can also contribute to immunopathology. Infectious disease researchers use this kit to:

• Monitor IL-17 levels in bacterial and fungal infection models
• Study IL-17's role in neutrophil recruitment and pathogen clearance
• Investigate IL-17 dysregulation in chronic infections
• Assess IL-17 as a biomarker of infection severity

Cancer Research: Tumor Inflammation and Immune Evasion

IL-17 can promote tumor-associated inflammation and immune suppression in the tumor microenvironment. Oncology researchers use this kit to:

• Quantify IL-17 in tumor microenvironment studies
• Monitor IL-17 levels in cancer patient serum/plasma
• Study IL-17's role in tumor progression and metastasis
• Assess the effects of immunotherapy on IL-17 production

Why Choose This Kit for Your IL-17 Research?

Kit Components at a Glance

• Human IL-17 microplate
• Human IL-17 standard
• Human IL-17 detect antibody
• EliKine™ Streptavidin-HRP
• Standard diluent, assay buffer, HRP substrate, stop solution, wash buffer, plate covers[reference:140]

🔬 Which research field does your work belong to?
Autoimmune Disease | Inflammation Research | Infectious Disease | Cancer Research | Other
Share your application with us — we'd love to hear how you're using this kit in your studies!

📌 Reference Link: EliKine™ Human IL-17 ELISA Kit — KTE6022