CheKine™ Micro G6Pase Assay Kit: Powering Diabetes, Metabolism, and Liver Research

Diabetes & Glucose Homeostasis

Glucose-6-phosphatase (G6Pase, EC 3.1.3.9) is widely present in animals, plants, microorganisms, and cells[reference:73]. It is the rate-limiting enzyme in gluconeogenesis — the pathway that produces glucose from non-carbohydrate precursors — and plays an important role in ensuring blood glucose homeostasis[reference:74].

Abbkine's CheKine™ Micro Glucose-6-Phosphatase (G6P) Activity Assay Kit (KTB1014) is essential for[reference:75]:

• Type 2 diabetes research — understanding hepatic glucose overproduction
• Insulin resistance studies — measuring G6Pase dysregulation
• Anti-diabetic drug screening — identifying G6Pase inhibitors
• Fasting/feeding metabolic transitions

Liver Disease & Hepatology

The liver is the primary site of G6Pase activity. The kit enables:

• NAFLD/NASH research (altered gluconeogenesis in fatty liver)
• Liver fibrosis and cirrhosis studies
• Hepatocyte function assessment in culture models
• Drug-induced liver injury (DILI) evaluation

Published in Nature Communications: The kit was used in a study on the hypothalamus-sympathetic-liver axis mediating the early phase of stress-induced hyperglycemia (IF: 15)[reference:76]. Another study showed that KTB1014 revealed a 40% G6P surge in insulin-resistant vs. healthy mouse livers[reference:77].

Broader Applications

G6Pase is widely distributed in animals, plants, and microorganisms[reference:78]. The kit supports:

• Plant metabolism — understanding sugar partitioning
• Microbial physiology — studying carbon flux
• Developmental biology — tracking metabolic maturation

What You Get

The kit includes Extraction Buffer, Reagent I, and Reagent II[reference:79]. Features include[reference:80]:

• Simple operation steps
• Detailed sample preparation and result calculation methods
• 12-month stability at 4°C[reference:81]

📊 Your Research Area?
Diabetes | Metabolism | Hepatology | Drug Discovery | Plant Science

👉 Measure G6Pase activity accurately. View Product