Descriptions:Recombinant SARS-CoV-2 Spike RBD Protein, His tag (Animal-Free), expressed in HEK 293 Cells
Tags:SARS-CoV-2 Spike RBD
Descriptions:Interleukin 29 (IL-29) is a cytokine, predicts a molecular mass of 21.9 kDa. It belongs to type III interferons group, also termed interferons λ (IFN-λ). Its induction of STAT3-STAT5 has also been displayed, albeit to a lesser degree. The STAT1 /STAT2 signaling cascade transpires as follows: once tyrosine residues on STAT1 and STAT2 are phosphorylated, these proteins dimerize and are subsequently transported to the nucleus.
Tags:IL-29
Descriptions:C-X-C motif chemokine 5 (CXCL5) also named epithelial-derived neutrophil-activating peptide 78 (ENA-78), which is a chemokine of the intercrine alpha family. CXCL5 is a 8.2 kDa protein containing 74 amino acid residues. CXCL5 is stimulated by the IL-1 or TNFα during inflammation which produced by the eosinophils and CXCL5 is inhibited by the IFNγ.CXCL5 promotes the formation of blood vessels and angiogenesis by binding the cell receptor CXCR2.
Tags:CXCL5
Descriptions:Pleiotrophin (PTN) also known as HB-GAM, which is a Growth Factors involves in widely range of biological events such as bone development, neural regeneration, inflammatory response, tissue repair. PTN is 18.9 kDa protein containing 168 residues that expressed in Osteoblast and brain. Besides, PTN has been revealed to suppress the long-term potentiation (LTP) in hippocampus and plays a critical role in modulating learning-related behavior. On the other hand, PTN also acts as an angiogenic factor that promotes tumor progression by PTN/Anaplastic Lymphoma Kinase (ALK) axis.
Applications:His tag
Tags:Pleiotrophin
Descriptions:GDF-3(以前称为Vgr-2)是TGF-β超家族成员,属于生长/分化因子家族。GDF-3在未分化的胚胎干细胞(ES细胞)、白色脂肪组织和脑中表达。小鼠GDF-3由366个氨基酸组成,包含一个22个氨基酸的信号序列、一个230个氨基酸的前肽和一个114个氨基酸的成熟蛋白,该成熟蛋白含有一个潜在的N-糖基化位点。成熟区包含一个在家族成员中保守的半胱氨酸结结构。然而,它缺少负责形成分子间二硫键的第四个半胱氨酸,因此GDF-3可能以非共价同型二聚体的形式存在。成熟的人GDF-3与小鼠和大鼠GDF-3的氨基酸序列同一性分别为83%和83%。大部分GDF-3以未裂解的前原形式存在。未分裂形式和成熟形式似乎均具有活性,但活性可能有所不同。所有形式均可对抗BMP。在ES细胞中,GDF-3抑制BMP2信号传导可维持多能性。GDF-3还影响早期细胞命运决定;例如,删除小鼠GDF-3会导致原肠胚形成前胚胎的前内脏内胚层出现缺陷。GDF-3在胚胎发生过程中与GDF-1协同作用,成熟蛋白具有类似节点的活性。虽然GDF家族成员通过BMP受体(ALK1、2、3和6)发出信号,从而激活Smads 1、5和8,但也有报道称GDF-3通过ALK4和ALK7发出信号,从而激活Smads 2和3。在脂肪细胞中,高脂饮食会诱导GDF-3,从而促进脂肪生成和肥胖。
Tags:GDF3
Descriptions:Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) is secreted by a number of different cell types (including activated T cells,Bcells,macrophages,mast cells,endothelial cells and fibroblasts) in response to cytokine or immune and inflammatory stimulation.
Applications:His tag
Tags:M-CSF
Descriptions:Abbkine Protein Quantification Kit (BCA Assay) provides a simple, rapid, detergent-compatible procedure for the detection and quantitation of total protein.
Tags:BCA
Descriptions:Mouse IL-1β protein, expressed in E. coli
Tags:IL-1β
Descriptions:Mouse IL-1α protein expressed in E. coli
Tags:IL-1α