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Neuregulin-2 Polyclonal Antibody

Neuregulin-2 Polyclonal Antibody

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Specification

Product name Neuregulin-2 Polyclonal Antibody
Immunogen Synthesized peptide derived from the Internal region of human Neuregulin-2
Host Rabbit
Reactivity Human, Mouse, Rat
Applications ELISA, IHC-P, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:20000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative NRG2; NTAK; Pro-neuregulin-2, membrane-bound isoform; Pro-NRG2

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background NRG2 encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described.
Gene ID 9542
Alternative NRG2; NTAK; Pro-neuregulin-2, membrane-bound isoform; Pro-NRG2
Others Neuregulin-2 Polyclonal Antibody detects endogenous levels of Neuregulin-2 protein.
Accession O14511
Observed Band(KD) 90

Image & description

Fig.1. Western Blot analysis of HT29 cells using Neuregulin-2 Polyclonal Antibody. Secondary antibody (catalog#: A21020) was diluted at 1:20000.

Fig.1. Western Blot analysis of HT29 cells using Neuregulin-2 Polyclonal Antibody. Secondary antibody (catalog#: A21020) was diluted at 1:20000.

Fig.2. Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:100.

Fig.2. Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:100.

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