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MCM6 Polyclonal Antibody

MCM6 Polyclonal Antibody

Views(40) Publications(0) Catalog no(ABP53185)
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Specification

Product name MCM6 Polyclonal Antibody
Immunogen Synthesized peptide derived from the Internal region of human MCM6
Host Rabbit
Reactivity Human, Mouse, Rat
Applications ELISA, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:20000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative MCM6; DNA replication licensing factor MCM6; p105MCM

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background DNA replication licensing factor MCM6 encoded by MCM6 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood.
Gene ID 4175
Alternative MCM6; DNA replication licensing factor MCM6; p105MCM
Others MCM6 Polyclonal Antibody detects endogenous levels of MCM6 protein.
Accession Q14566
Observed Band(KD) 90

Image & description

Fig. Western Blot analysis of hela cells using MCM6 Polyclonal Antibody . Secondary antibody (catalog#: A21020) was diluted at 1:20000.

Fig. Western Blot analysis of hela cells using MCM6 Polyclonal Antibody . Secondary antibody (catalog#: A21020) was diluted at 1:20000.

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