| Product name | Human IL-36α protein |
| Sequence | Amino acid sequence derived from Human IL-36 α (Q9UHA7) (Lys6-Phe158) was expressed. |
| Protein length | The recombinant Human IL-36α consists of 153 amino acids and has a predicted molecular mass of 17 KD. |
| Preparation method | E. coli |
| Purity | >98% as determined by SDS-PAGE |
| Alternative | Interleukin-36 Alpha; FIL1 Epsilon; Interleukin-1 Epsilon; IL-1 Epsilon; Interleukin-1 Family Member 6; IL-1F6; IL36A; FIL1E; IL1E; IL1F6 |
| Formulation | Lyophilized from sterile PBS, pH 7.4. |
| Features & Benefits | Endotoxin: < 0.1 EU per µg of the protein as determined by the LAL method. |
| Molecular weight | 17 KD |
| Usage notes | Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human IL36 alpha protein using the buffer we provided not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. |
| Storage instructions | Lyophilized Human IL-36α proteinshould be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.18% HSA or BSA). Please prevent freeze-thaw cycles. |
| Shipping | The product is shipped at ambient temperature. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | Human IL-36 α previously called IL-1F6 and FIL-1 epsilon (family of IL-1 member epsilon), is a member of the IL-1 family which includes IL-1b, IL-1a, IL-1ra, IL-18, IL-36ra (IL-1F5), IL-36b (IL-1F8), IL-36g (IL-1F9), IL-37 (IL-1F7) and IL-38 (IL-1F10). IL-36a is a pro-inflammatory cytokine which plays an important role in innate and adaptive immunity. IL-36a is expressed in the immune system and the fetal brain, but not in other tissues or multiple hematopoietic cell lines.IL-36 α, β, and gamma all activate NF-kappa B and MAPK pathways in an IL‑1 Rrp2 dependent manner, and induce production of inflammatory cytokines and chemokines such as CXCL8/IL-8. IL-36 α and other family members are overexpressed in psoriatic skin lesions, and transgenic overexpression of IL‑36 α in skin keratinocytes produces epidermal hyperplasia. |
| Gene ID | 27179 |
| Alternative | Interleukin-36 Alpha; FIL1 Epsilon; Interleukin-1 Epsilon; IL-1 Epsilon; Interleukin-1 Family Member 6; IL-1F6; IL36A; FIL1E; IL1E; IL1F6 |
| Accession | Q9UHA7 |
Fig. SDS-PAGE analysis of Human IL36 alpha protein, N-His tag.
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1.The species of antibody reactivity should be the sample species that can be matched normally after Abbkine R&D experts have passed strict scientific verification. If your sample is not within the range of reactivity, in order to improve the efficiency and results of your experiment, it is not suggested to try other species. Otherwise, it may lead to sample mismatch and affect the effect of your experiment.
2.Please aliquot the antibody received as soon as possible and store it at -20℃, avoid repeated freezing and thawing, and use it within one year.
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