Human OPG ELISA Kit: Precision Quantification of the Master Osteoclast Regulator

OPG: The Bone Metabolism Biomarker You Can't Afford to Misquantify

Osteoprotegerin (OPG) is a secreted cytokine that functions as a decoy receptor for RANKL, blocking osteoclast differentiation and bone resorption[reference:0]. Its dysregulation is implicated in osteoporosis, rheumatoid arthritis, cancer metastasis, and cardiovascular calcification. Accurate OPG quantification is therefore indispensable for bone biology, oncology, and metabolic research.

Yet many commercial OPG ELISA kits suffer from cross-reactivity with TNFRSF11B homologs, narrow dynamic ranges, and inconsistent lot-to-lot performance.

Superior Specificity: No Cross-Reactivity, No False Signals

Abbkine's Human OPG ELISA Kit (KTE60224) employs a two-site sandwich ELISA format with a monoclonal antibody specific for TNFRSF11B pre-coated onto the microplate[reference:1]. The kit demonstrates no significant cross-reactivity or interference between Human TNFRSF11B and its analogues[reference:2]—a critical advantage over generic kits that struggle with specificity in complex biological matrices like serum and plasma.

Validated Sample Types: From Serum to Cell Culture

Complete Kit Components – Everything You Need

The kit includes pre-coated microplate, lyophilized standard, biotin-conjugated detection antibody, Streptavidin-HRP, standard diluent, assay buffer, HRP substrate, stop solution, wash buffer, and plate covers[reference:3]. No additional reagents required.

Storage and Stability

Unopened kits should be stored at 2–8°C[reference:4]. All components are stable through the expiration date when stored properly.

Why Choose KTE60224?

The Bottom Line

Whether you're studying osteoclast regulation, bone metastasis, or inflammatory bone loss, KTE60224 delivers the specificity and reliability your research demands.

📎 Reference: Human Osteoprotegerin (OPG) ELISA Kit (KTE60224)