CheKine™ Micro Creatinine Assay Kit: Applications Across Renal Research and Beyond

Nephrology & Kidney Function Research

Creatinine is the gold-standard biomarker for glomerular filtration rate (GFR)[reference:39]. Abbkine's CheKine™ Micro Creatinine (Cr) Content Assay Kit (KTB1002) enables precise quantification of creatinine in serum, plasma, urine, and other liquid samples[reference:40] — essential for:

• Acute kidney injury (AKI) models
• Chronic kidney disease (CKD) progression studies
• Nephrotoxicity screening in drug development
• Diabetic nephropathy research

The kit detects creatinine via a three-enzyme cascade: creatinine → creatine → sarcosine → hydrogen peroxide → colored quinimine compound (absorbance at 546 nm)[reference:41]. The calibration range spans 20-8,000 μmol/L with a detection limit of 20 μmol/L[reference:42].

Metabolic & Endocrine Research

Beyond nephrology, creatinine measurement is valuable in:

• Muscle metabolism studies — creatinine is a direct product of muscle creatine phosphate breakdown[reference:43]
• Endocrinology — monitoring metabolic changes in hormonal disorders
• Aging research — tracking age-related renal function decline

Toxicology & Drug Safety

The kit contains anti-interference components such as ascorbic acid oxidase and EMse447, which effectively eliminate interference from endogenous substances and other drugs in the sample[reference:44]. This makes KTB1002 ideal for:

• Preclinical pharmacokinetic studies
• Environmental toxicology
• Heavy metal nephrotoxicity assessment

Sample Compatibility & Storage

Validated for animal tissues, serum, plasma, urine, and other liquid samples[reference:45]. Store at 4°C for up to 12 months, protected from light[reference:46]. If not assayed immediately, samples can be stored at -80°C for one month[reference:47].

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Nephrology | Metabolism | Toxicology | Endocrinology | Aging

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