Descriptions:Active matrix metalloproteinase-7 (Active MMP-7) is a 20.07 kDa matrix metalloproteinases with 180 amino acid residues. MMP-7 restricted production by normal mucosal and exocrine gland epithelial cells, as well as by carcinoma cells. Functionally, it involved breakdown of extracellular matrix (casein, gelatins of types I, III, IV, and V, and fibronectin) in normal physiological processes and disease processes. MMP-7 is contributed to early tumor development during carcinogenesis.
Tags:MMP7 (active)
Descriptions:C-X-C motif chemokine 12 (CXCL12) also named stromal cell-derived factor 1 (SDF-1), which is a chemokine of the intercrine alpha family. CXCL12 is a 7.8 kDa protein containing 70 amino acid residues. CXCL12 has a key role in controling the immune responses which is often induced by the lipopolysaccharide or IL-1. CXCL12 also activates the leukocytes during inflammation. CXCL12 induces the migration and proliferation of cells like hematopoietic progenitor, stem cells and leukocytes.
Tags:CXCL12
Descriptions:Interleukin-15 (IL-15) is a 14-15 kDa glycoprotein with immune regulatory functions in many diverse cell types. IL-15 can be constitutively expressed in a variety of cell types stored as intracellular protein in the cytoplasm as well as transport to the cell surface, while only secreted from some cell types including monocytes, dendritic cells, epithelial cells, bone marrow stromal cells, and fibroblasts. As a pleiotropic cytokine, IL-15 mediates the crosstalk between innate immunity and adaptive immunity whose principal role is to kill virally infected cells. IL-15 plays a crucial role in the development, differentiation, and survival of NK cells. In monocytes, IL-15 induces the production of IL-8 and monocyte chemotactic protein 1 (MCP-1), which recruits neutrophils and monocytes to sites of infection. IL-15 can also act as a chemo-attractant in T lymphocytes and regulate the differentiation of T lymphocytes.
Tags:IL-15
Descriptions:Mouse IL-7 Protein, His tag (Animal-Free), expressed in E. coli
Tags:IL-7
Descriptions:Bone Morphogenetic Protein-14 (BMP-14), known as Growth differentiation factor 5 (GDF5), is an extracellular multifunctional cytokine that is also a member of the TGFβ family. BMP-14 can bind with the TGFβ receptor and trigger SMAD protein signal transduction. BMP-14 plays a role in skeletal and joint development and increases the survival of neurons that respond to the neurotransmitter dopamine.
Applications:His tag
Tags:BMP-14
Descriptions:Fms相关酪氨酸肽3配体(Flt-3配体)是由小鼠Flt3lg基因编码的蛋白质。Flt-3配体作为造血的重要调节因子,酪氨酸肽3配体有活性,可刺激淋巴系和髓系造血祖细胞的增殖。Flt-3配体可配合使用他的细胞因子(如GM-CSF、G-CSF、IL-3、EPO、IL-11、IL-12、IL-6或TPO)很好地促进未成熟造血细胞的增殖。Flt-3配体在多种造血祖细胞中表达,包括未成熟造血细胞和骨髓基质细胞。
Tags:Flt-3 Ligand
Descriptions:FGF16 is preferentially expressed in the heart after birth, suggesting its regulation is associated with tissue-specific chromatin remodeling and DNA-protein interactions. Mutation of the MEF2 site resulted in a blunting of FGF16 promoter activity in transfected neonatal rat cardiac myocytes, that chromatin remodeling and MEF2 binding in the FGF16 promoter contribute to expression in the postnatal heart.
Tags:FGF16
Descriptions:This Rat Troponin T, fast skeletal muscle (TNNT3) ELISA Kit employs a two-site sandwich ELISA to quantitate TNNT3.
Reactivity:Rat
Applications:ELISA
Tags:TNNT3