Descriptions：Interleukin 31 (IL-31) is an 18 kDa cytokine with 142 amino acid residues. IL-31 is mainly secreted from activated CD4+ T cells and binds to a receptor called IL-31RA. Upon binding to 31RA, IL-31 activates several signal pathways like MAPK, PI3K/AKT, and Jak/STAT pathways. It is critical in regulating many biological functions, such as cell proliferation, hematopoiesis, induction of cytokines, inflammation, and immune response.
Applications：His tag
Tags：IL-31
Descriptions：Glycolate Oxidase (GO)
Descriptions：Interleukin 9, also known as IL-9, is a pleiotropic cytokine (cell signalling molecule) belonging to the group of interleukins. IL-9 is produced by variety of cells like mast cells, NKT cells, Th2, Th17, Treg, ILC2, and Th9 cells in different amounts. Among them, Th9 cells are regarded as the major CD4+ T cells that produce IL-9.
Applications：His tag
Tags：IL-9
Descriptions：Transforming Growth Factors beta 2 (TGFβ-2) is a 12.85 kDa member of the epidermal Growth Factors with 113 amino acid residues. TGFβ-2 is expressed from throughout the body. TGFβ-2 is a regulator of cell proliferation, differentiation, apoptosis, cell plasticity and migration, etc. TGF-β-2 also associates with various kinds of diseases, such as cancer and tissue fibrosis.
Applications：His tag
Tags：TGF-β2
Descriptions：C-X-C motif chemokine 13 (CXCL13) also named B lymphocyte chemoattractant (BLC), which is a chemokine of the intercrine alpha family. CXCL13 is a 7.9kDa protein containing 72 amino acid residues. CXCL13 is a chemotaxis for B lymphocyte. CXCL13 induces the cell proliferation though the AKT signal pathway which plays a key role intestinal cancer model. CXCL13 /CXCR5 axis is highly existed in gut, spleen and lymph nodes.
Applications：His tag
Tags：CXCL13
Descriptions：Fms-related tyrosine kinase-3 ligand (Flt-3 Ligand) is a protein which is encoded by the FLT3LG gene in human. As an important regulator of hematopoiesis, Flt-3 ligand has a tyrosine-protein kinase activity that stimulate the proliferation of hematopoietic progenitor cells of both lymphoid and myeloid origin. Flt-3 ligand can synergistically increase the proliferation of immature progenitors with other cytokines such as GM-CSF, G-CSF, IL-3, EPO, IL-11, IL-12, IL-6 or TPO. Flt-3 ligand is expressed by a variety of hematopoietic progenitor cells including immature hematopoietic and
Applications：His tag
Tags：Flt-3 Ligand
Descriptions：Heparin Binding Growth Factors (HDGF) is a 27.6 kDa hepatoma-derived Growth Factors with 246 amino acid residues. HDGF is mainly expressed from mitochondria and proteasome. Functionally, it is a potent mitogen, stimulating the growth of vascular smooth muscle cells, hepatoma cells and endothelial cells, acting as a transcriptional repressor. HDGF is expressed in a variety of cancers.
Applications：His tag
Tags：HDGF
Descriptions：Human IFN-α1a Protein, His tag (Animal-Free), expressed in E. coli
Applications：His tag
Tags：IFN-α1a
Descriptions：GDF-3 (previously called Vgr-2) is a TGF-beta superfamily member belonging to the growth/differentiation factor family. GDF-3 is expressed in undifferentiated embryonic stem (ES) cells, white adipose tissue and the brain. The 366 amino acid (aa) mouse GDF-3 contains a 22 aa signal sequence, a 230 aa propeptide and a 114 aa mature protein that contains one potential N-glycosylation site. The mature region contains a cysteine-knot structure that is conserved throughout family members. However, it lacks the fourth cysteine which is responsible for the formation of an inter-molecular disulfide bond, so GDF-3 may exist as a non-covalent homodimer. Mature human GDF-3 shares 83%, 83% aa sequence identity with mouse and rat GDF-3. Most of GDF-3 is present as the uncleaved prepro form. The uncleaved and the mature forms both appear to have activity, but that activity may differ. All forms can oppose BMPs. In ES cells, inhibition of BMP2 signaling by GDF-3 maintains pluripotency. GDF-3 also influences early cell fate decisions; for example, deletion of mouse GDF-3 produces defects in the anterior visceral endoderm of the pre-gastrulation embryo. GDF-3 cooperates with GDF-1 in embryogenesis, and the mature protein has nodal-like activity. Although GDF family members signal through BMP receptors (ALK1, 2, 3 and 6), which activate Smads 1, 5 and 8, GDF-3 signaling through ALK4 and ALK7, which activate Smads 2 and 3, has also been reported. In adipocytes, GDF-3 is induced by a high fat diet, promoting adipogenesis and obesity.
Applications：No tag
Tags：GDF3
