Descriptions:抑瘤素M (OSM)是一种糖蛋白,属于白细胞介素-6 (IL-6)细胞因子家族,该家族包括循环抑制因子、细胞集落刺激因子和白细胞介素-6。OSM是一种编码生长调节因子,可抑制多种肿瘤细胞系的增殖。它刺激AIDS-KS颗粒细胞的增殖。OSM调节细胞因子的产生,包括内皮细胞产生的IL-6、G-CSF和GM-CSF。OSM被许多认为是一种多效性细胞因子,通过特定的细胞表面摄取启动其生物活性。低亲和力含有gp130的蛋白质相似,现已被鉴定为高亲和力OSM受体的组成部分,可传递OSM信号。OSM还被证明在促炎和抗炎作用中发挥作用。OSM可能参与生物过程,包括胚胎发育、造血、通道重建、形成和破坏以及可能的中枢系统发育。
Tags:OSM
Descriptions:Interleukin 36 gamma (IL-36 gamma) is a 17.65 kDa cytokine with 159 amino acid residues. IL-36 gamma is a member of the IL-1 family and is mainly expressed in keratinocytes, bronchial epithelial cells, macrophages, and monocyte. This cytokine responds to multiple pathogen-associated molecular patterns (PAMPs) and participates in the inflammatory response. In addition, it also induces the production of pro-inflammatory cytokines like IL-12, IL-1β, IL-6, TNF-α, and IL-23.
Applications:His tag
Tags:IL-36γ
Descriptions:Interleukin 17F (IL-17F) predicts a molecular mass of 30.1 kDa, is a cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. It is involved in the development of inflammation and host defense against infection by inducing the expression of genes that encode other proinflammatory cytokines, such as tumor necrosis factor, interleukin 1, interleukin 6 and some members of the colony-stimulating factor family.
Applications:His tag
Tags:IL-17F
Descriptions:Human IL-36γ protein, expressed in E. coli
Tags:IL-36γ
Descriptions:Fibroblast Growth Factors-10 (FGF-10) is a 23.4 kDa member of the fibroblast Growth Factors with 208 amino acid residues. FGF-10 is mainly secreted from endometrial stromal cells, fibroblasts, peritubular cells, leydig cells, muller glia cells. FGF-10 a multifunctional mesenchymal-epithelial signaling Growth Factors, can regulate embryonic development, cell proliferation and cell differentiation. It has been associated with cancer and human genetic disorders.
Tags:FGF-10
Descriptions:Vascular Endothelial Growth Factors 121 (VEGF121) is a truncated version of VEGF165, which produced in E. coli is a homodimer, non-glycosylated, polypeptide chain and having a molecular mass of 28.4 kDa. There is three different isoforms (120, 164 and 188 a.a.) found in mouse. VEGF 121 shows that lack basic heparin-binding regions and are freely diffusible. Mouse VEGF121 shares 98% identity with corresponding regions of rat, 89% with canine, feline, equine and porcine, and 87% with human, ovine and bovine VEGF, respectively.
Tags:VEGF121
Descriptions:Bone morphogenetic proteins (BMPs) are a group of growth factors also known as cytokines and as metabologens. BMP-12 regulates chondrogenesis, bone morphogenesis, and neuron differentiation.
Applications:His tag
Tags:BMP-12