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TWEAK Polyclonal Antibody

TWEAK Polyclonal Antibody

Views(375) Publications(0) Catalog no(ABP52658)
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Specification

Product name TWEAK Polyclonal Antibody
Immunogen Synthesized peptide derived from the Internal region of human TWEAK at AA range: 10-90
Host Rabbit
Reactivity Human, Mouse
Applications ELISA, IF, IHC-P, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), IF (1:200-1:1000), ELISA (1:20000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative TNFSF12; APO3L; DR3LG; Tumor necrosis factor ligand superfamily member 12; APO3 ligand; TNF-related weak inducer of apoptosis; TWEAK

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background Tumor necrosis factor ligand superfamily member 12 encoded by TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID: 407977, TNFSF12-TNFSF13.
Gene ID 8742
Alternative TNFSF12; APO3L; DR3LG; Tumor necrosis factor ligand superfamily member 12; APO3 ligand; TNF-related weak inducer of apoptosis; TWEAK
Others TWEAK Polyclonal Antibody detects endogenous levels of TWEAK protein.
Accession O43508
Observed Band(KD) 27

Image & description

Fig.1. Western Blot analysis of various cells using TWEAK Polyclonal Antibody diluted at 1:2000. Secondary antibody (catalog#: A21020) was diluted at 1:20000.

Fig.1. Western Blot analysis of various cells using TWEAK Polyclonal Antibody diluted at 1:2000. Secondary antibody (catalog#: A21020) was diluted at 1:20000.

Fig.2. Western Blot analysis of 293 cells using TWEAK Polyclonal Antibody diluted at 1:2000. Secondary antibody (catalog#: A21020) was diluted at 1:20000.

Fig.2. Western Blot analysis of 293 cells using TWEAK Polyclonal Antibody diluted at 1:2000. Secondary antibody (catalog#: A21020) was diluted at 1:20000.

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