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tPA Polyclonal Antibody

tPA Polyclonal Antibody

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Specification

Product name tPA Polyclonal Antibody
Immunogen Synthesized peptide derived from the N-terminal region of human tPA
Host Rabbit
Reactivity Human, Mouse, Rat
Applications ELISA, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative PLAT; Tissue-type plasminogen activator; t-PA; t-plasminogen activator; tPA; Alteplase; Reteplase

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background PLAT (plasminogen activator, tissue type) encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of PLAT results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Gene ID 5327
Alternative PLAT; Tissue-type plasminogen activator; t-PA; t-plasminogen activator; tPA; Alteplase; Reteplase
Others tPA Polyclonal Antibody detects endogenous levels of tPA protein.
Accession P00750
Observed Band(KD) 63

Image & description

Fig. Western Blot analysis of A549 cells using tPA Polyclonal Antibody. Secondary antibody was diluted at 1:20000.

Fig. Western Blot analysis of A549 cells using tPA Polyclonal Antibody. Secondary antibody was diluted at 1:20000.

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