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Rad50 Polyclonal Antibody

Rad50 Polyclonal Antibody

Views(450) Publications(0) Catalog no(ABP52307)
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Specification

Product name Rad50 Polyclonal Antibody
Immunogen Synthesized peptide derived from the Internal region of human Rad50 at AA range: 650-730
Host Rabbit
Reactivity Human, Mouse, Rat
Applications ELISA, IHC-P, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:20000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative RAD50; DNA repair protein RAD50; hRAD50

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background RAD50 double strand break repair protein encoded by RAD50 is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. RAD50 double strand break repair protein forms a complex with MRE11 and NBS1. RAD50 double strand break repair protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. RAD50 double strand break repair protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest RAD50 is essential for cell growth and viability. Mutations in RAD50 are the cause of Nijmegen breakage syndrome-like disorder.
Gene ID 10111
Alternative RAD50; DNA repair protein RAD50; hRAD50
Others Rad50 Polyclonal Antibody detects endogenous levels of Rad50 protein.
Accession Q92878
Observed Band(KD) 153

Image & description

Fig. Western Blot analysis of various cells using Rad50 Polyclonal Antibody diluted at 1:1000.

Fig. Western Blot analysis of various cells using Rad50 Polyclonal Antibody diluted at 1:1000.

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