| Product name | KOR-1 (phospho Ser369) Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from human KOR-1 around the phosphorylation site of S369 |
| Host | Rabbit |
| Reactivity | Mouse,Rat |
| Applications | WB,IHC,IF,ELISA |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200 |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Alternative | OPRK1; OPRK; Kappa-type opioid receptor; K-OR-1; KOR-1 |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Molecular weight | 42kD |
| Storage buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | Endogenous opioid peptides and opiates, like morphine, transmit their pharmacological effects through membrane bound opioid receptors. Pharmacological studies and molecular cloning have led to the identification of three different types of opioid receptor, mu-type, delta-type and kappa-type, also designated MOR-1, DOR-1 and KOR-1, respectively. MOR-1 is a receptor for beta-endorphin, DOR-1 is a receptor for enkephalins, and KOR-1 is a receptor for dynorphins.The three opioid receptor types are highly homologous and belong to the superfamily of G-protein-coupled receptors. Opioid receptors have been shown to modulate a range of brain functions, including instinctive behavior and emotions. This regulation is thought to involve the inhibition of neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. |
| Alternative | OPRK1; OPRK; Kappa-type opioid receptor; K-OR-1; KOR-1 |
| Others | Phospho-KOR-1 (S369) Polyclonal Antibody detects endogenous levels of KOR-1 protein only when phosphorylated at S369. |
| Observed Band(KD) | 42 |
Fig.1. Western Blot analysis of various cells using Phospho-KOR-1 (S369) Polyclonal Antibody diluted at 1:1000.
Fig.2. Western Blot analysis of Rat-kidney cells using Phospho-KOR-1 (S369) Polyclonal Antibody diluted at 1:1000.
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