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Human IFN-γ protein, His Tag

Human IFN-γ protein, His Tag

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Specification

Product name Human IFN-γ protein, His Tag
Sequence Amino acid sequence derived from Human IFN-γ soluble form (NP_01579.1) (Gln24-Gln166) was expressed, was expressed with a polyhistidine tag at the N-terminus.
Protein length The recombinant Human IFN-γ protein consists of 164 amino acids and predicts a molecular mass of 18.0 kDa.
Preparation method E. coli
Purity > 95 % as determined by SDS-PAGE
Alternative IFG; IFI; IFN gamma; Interferon Gamma; Interferon gamma; IFNG

Product Properties

Formulation Lyophilized from sterile 150mM NaCl 20mM Tris , pH 7.0.
Molecular weight 18.0 kDa
Usage notes Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human IFN-gamma protein in sterile ddH2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Storage instructions Lyophilized Human IFN-γ protein, His Tagshould be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.5% HSA or BSA). Please prevent freeze-thaw cycles.
Shipping The product is shipped at ambient temperature.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background IFN-γ, also known as IFNG, is a secreted protein which belongs to the type I I interferon family. IFN-γ is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte effector T cells once antigen-specific immunity develops. IFN-γ has antiviral, immunoregulatory, and anti-tumor properties. IFNG, in addition to having antiviral activity, has important immunoregulatory functions, it is a potent activator of macrophages, and has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. The IFNG monomer consists of a core of six α-helices and an extended unfolded sequence in the C-terminal region. IFN-γ is critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Aberrant IFN-γ expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFN-γ in the immune system stems in part from its ability to inhibit viral replication directly, and most importantly from its immunostimulatory and immunomodulatory effects. IFNG also promotes NK cell activity.
Gene ID 3458
Alternative IFG; IFI; IFN gamma; Interferon Gamma; Interferon gamma; IFNG
Accession P01579

Image & description

Fig.SDS-PAGE analysis of Human IFN-gamma protein.

Fig.SDS-PAGE analysis of Human IFN-gamma protein.

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