| Product name | HDAC4 Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from human HDAC4 around the non-phosphorylation site of S632 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, WB |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:20000). Not yet tested in other applications. |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Alternative | HDAC4; KIAA0288; Histone deacetylase 4; HD4 |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Storage buffer | PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. Histone deacetylase 4 encoded by HDAC4 belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. Histone deacetylase 4 does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. |
| Gene ID | 9759 |
| Alternative | HDAC4; KIAA0288; Histone deacetylase 4; HD4 |
| Others | HDAC4 Polyclonal Antibody detects endogenous levels of HDAC4 protein. |
| Accession | P56524 |
| Observed Band(KD) | 119 |
Fig.1. Western Blot analysis of various cells using HDAC4 Polyclonal Antibody diluted at 1:2000.
Fig.2. Western Blot analysis of hela cells using HDAC4 Polyclonal Antibody diluted at 1:2000.
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