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Fibulin-5 Polyclonal Antibody

Fibulin-5 Polyclonal Antibody

Views(15) Publications(0) Catalog no(ABP51345)
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Specification

Product name Fibulin-5 Polyclonal Antibody
Immunogen Synthesized peptide derived from the Internal region of human Fibulin-5 at AA range: 140-220
Host Rabbit
Reactivity Human, Mouse, Rat
Applications ELISA, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative FBLN5; DANCE; Fibulin-5; FIBL-5; Developmental arteries and neural crest EGF-like protein; Dance; Urine p50 protein; UP50

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background Fibulin-5 encoded by FBLN5 is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3).
Gene ID 10516
Alternative FBLN5; DANCE; Fibulin-5; FIBL-5; Developmental arteries and neural crest EGF-like protein; Dance; Urine p50 protein; UP50
Others Fibulin-5 Polyclonal Antibody detects endogenous levels of Fibulin-5 protein.
Accession Q9UBX5
Observed Band(KD) 50

Image & description

Fig.1. Western Blot analysis of various cells using Fibulin-5 Polyclonal Antibody diluted at 1:1000.

Fig.1. Western Blot analysis of various cells using Fibulin-5 Polyclonal Antibody diluted at 1:1000.

Fig.2. Western Blot analysis of L929 cells using Fibulin-5 Polyclonal Antibody diluted at 1:1000.

Fig.2. Western Blot analysis of L929 cells using Fibulin-5 Polyclonal Antibody diluted at 1:1000.

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