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Connexin 43 (phospho Ser368) Polyclonal Antibody

Connexin 43 (phospho Ser368) Polyclonal Antibody

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Specification

Product name Connexin 43 (phospho Ser368) Polyclonal Antibody
Immunogen Synthesized peptide derived from human Connexin 43 around the phosphorylation site of S368
Host Rabbit
Reactivity Human, Mouse, Rat
Applications ELISA, IHC-P, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:20000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative GJA1; GJAL; Gap junction alpha-1 protein; Connexin-43; Cx43; Gap junction 43 kDa heart protein

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background GJA1 is a member of the connexin gene family. Gap junction protein alpha 1 is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Gap junction protein alpha 1 is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in GJA1 have been associated with oculodentodigital dysplasia, autosomal recessive craniometaphyseal dysplasia and heart malformations.
Gene ID 2697
Alternative GJA1; GJAL; Gap junction alpha-1 protein; Connexin-43; Cx43; Gap junction 43 kDa heart protein
Others Phospho-Connexin 43 (S368) Polyclonal Antibody detects endogenous levels of Connexin 43 protein only when phosphorylated at S368.
Accession P17302
Observed Band(KD) 43

Image & description

Fig.1. Western Blot analysis of various cells using Phospho-Connexin 43 (S368) Polyclonal Antibody diluted at 1:2000.

Fig.1. Western Blot analysis of various cells using Phospho-Connexin 43 (S368) Polyclonal Antibody diluted at 1:2000.

Fig.2. Western Blot analysis of HuvEc cells using Phospho-Connexin 43 (S368) Polyclonal Antibody diluted at 1:2000.

Fig.2. Western Blot analysis of HuvEc cells using Phospho-Connexin 43 (S368) Polyclonal Antibody diluted at 1:2000.

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