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Cleaved-Caspase-2 p18 (G170) Polyclonal Antibody

Cleaved-Caspase-2 p18 (G170) Polyclonal Antibody

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Specification

Product name Cleaved-Caspase-2 p18 (G170) Polyclonal Antibody
Immunogen Synthesized peptide derived from the Internal region of human Caspase-2 p18 at AA range: 120-200
Host Rabbit
Reactivity Human
Applications ELISA, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:40000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative CASP2; ICH1; NEDD2; Caspase-2; CASP-2; Neural precursor cell expressed developmentally down-regulated protein 2; NEDD-2; Protease ICH-1

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background CASP2 encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. Caspase 2 may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of CASP2 may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene ID 835
Alternative CASP2; ICH1; NEDD2; Caspase-2; CASP-2; Neural precursor cell expressed developmentally down-regulated protein 2; NEDD-2; Protease ICH-1
Others Cleaved-Caspase-2 p18 (G170) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-2 p18 protein resulting from cleavage adjacent to G170.
Accession P42575
Observed Band(KD) 18 or 35

Image & description

Fig.1. Western Blot analysis of various cells using Cleaved-Caspase-2 p18 (G170) Polyclonal Antibody diluted at 1:2000.

Fig.1. Western Blot analysis of various cells using Cleaved-Caspase-2 p18 (G170) Polyclonal Antibody diluted at 1:2000.

Fig.2. Western Blot analysis of Jurkat cells using Cleaved-Caspase-2 p18 (G170) Polyclonal Antibody diluted at 1:2000.

Fig.2. Western Blot analysis of Jurkat cells using Cleaved-Caspase-2 p18 (G170) Polyclonal Antibody diluted at 1:2000.

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