| Product name | CENPF Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from part region of human CENPF protein at amino acid sequence of 2190-2270 |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC,IF |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-300;IF 1:50-200 |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Alternative | Centromere protein F; CENP-F; AH antigen; Kinetochore protein CENPF; Mitosin |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Molecular weight | 353kD |
| Storage buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | CENPF (Centromere Protein F) encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. |
| Gene ID | 1063 |
| Alternative | Centromere protein F; CENP-F; AH antigen; Kinetochore protein CENPF; Mitosin |
| Others | The antibody detects endogenous levels of CENPF protein |
| Accession | P49454 |
| Observed Band(KD) | 353 |
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