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Caspase 12 Polyclonal Antibody

Caspase 12 Polyclonal Antibody

Views(278) Publications(0) Catalog no(ABP50853)
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Specification

Product name Caspase 12 Polyclonal Antibody
Immunogen Synthesized peptide derived from the Internal region of human Caspase12
Host Rabbit
Reactivity Human
Applications ELISA, IHC-P, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:40000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative CASP12; Inactive caspase-12; CASP-12

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. CASP12 is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of CASP12 mediates apoptosis in response to endoplasmic reticulum stress. However, in humans CASP12 contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for CASP12.
Gene ID 120329
Alternative CASP12; Inactive caspase-12; CASP-12
Others Caspase12 Polyclonal Antibody detects endogenous levels of Caspase12 protein.
Accession Q6UXS9
Observed Band(KD) 50

Image & description

Fig. Western Blot analysis of various cells using Caspase12 Polyclonal Antibody diluted at 1:500.

Fig. Western Blot analysis of various cells using Caspase12 Polyclonal Antibody diluted at 1:500.

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