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Atm Polyclonal Antibody

Atm Polyclonal Antibody

Views(72) Publications(0) Catalog no(ABP55349)
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Specification

Product name Atm Polyclonal Antibody
Immunogen Synthesized peptide derived from human Atm around the non-phosphorylation site of S1981
Host Rabbit
Reactivity Human, Mouse
Applications ELISA, IHC-P, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:300), ELISA (1:40000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative ATM; Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background The protein encoded by ATM belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
Gene ID 472
Alternative ATM; Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated
Others Atm Polyclonal Antibody detects endogenous levels of Atm protein.
Accession Q13315

Image & description

Fig. Western Blot analysis of Mouse-BRAIN K562 cells using Atm Polyclonal Antibody diluted at 1:500.

Fig. Western Blot analysis of Mouse-BRAIN K562 cells using Atm Polyclonal Antibody diluted at 1:500.

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