Descriptions：Interleukin 31 (IL-31) is a 15.65 kDa cytokine with 141 amino acid residues. IL-31 is mainly secreted from Th2 cells and binds to a receptor called IL-31RA. Upon binding to IL-31RA, IL-31 activates several signal pathways like MAPK, PI3K/AKT, and Jak/STAT pathways. It is critical in regulating many biological functions, such as cell proliferation, hematopoiesis, induction of cytokines, inflammation, and immune response. It also responds to an antigen by facilitating cell-mediated immunity.
Tags：IL-31
Descriptions：R-spondin 1 (RSPO1, Roof plate-specific Spondin 1) is a cysteine-rich secreted glycoprotein that belongs to the R-Spondin family. Structurally, R-spondin 1 harbors an N-terminal signal peptide, two cysteine-rich furin-like (FU1-FU2) domains, a thrombospondin (TSP) domain, and a basic amino acid-rich (BR) C-terminal domain. R-spondin 1 acts as a ligand for the leucine-rich repeat-containing G-protein coupled receptor (LGR) family (LGR4/5/6), subsequent clearing negative regulators ZNRF3/RNF43 from the membrane, leading to the availability of Wnt receptor and activating Wnt/β-catenin signaling. The signal cascade is essential for regulating stem cell proliferation, embryonic development, and tissue homeostasis.
Applications：His-SUMO tag
Tags：RSPO1/R-spondin 1
Descriptions：Bone Morphogenetic Protein-8 (BMP-8) is an extracellular multifunctional cytokine that is also a member of the TGF-β family. BMP-8 can bind with TGF-β receptor and is involved in SMAD protein signal transduction. In addition, BMP-8 participates in the downregulation of insulin secretion that lets the heat stabilize. Moreover, it participates in ossification and is essential to cartilage and hard bone development.
Applications：His tag
Tags：BMP-8a
Descriptions：Protopectin
Tags：Protopectin
Descriptions：Soil-Fluorescein Diacetate (S-FDA)
Descriptions：β-GD
Tags：β-GD
Descriptions：Granulocyte colony-stimulating factor(G-CSF) is a growth factor and an essential cytokine which belongs to the IL-6 superfamily.
Applications：His tag
Tags：G-CSF
Descriptions：Interleukin 38 (IL-38) is a 16.87 kDa cytokine with 152 amino acid residues and a member of the interleukin-1 (IL-1) family. IL-38 is primarily secreted from basal epithelia of the skin and B cells of the tonsil, spleen, and thymus. It plays essential roles in inflammation and host defense by mediating NF-κB, AP1, and JNK signaling pathways when IL-38 binds to the receptors like IL1RAPL1 and IL-36R. In addition, IL-38 participates in down-regulating cell proliferation, migration, and up-regulating IL-6 and IL-10.
Tags：IL-38
Descriptions：Galectin-4 (Gal-4) is a lectin family member and is one of the tandem repeat-type galectins containing two carbohydrate recognition domains (CRD) connected by a linker region in a single peptide chain. The CRD is responsible for β-galactoside binding, and several binding partners for galectin-4 have been identified, including human blood group antigens, glycoproteins, mucin like membrane MUC1, glycosphingolipids, and sulfated cholesterol. Galectin-4 is constitutively presented in the intestine and stomach, uterine epithelial cells, blood vessel walls, hippocampal and cortical neurons. It serves important functions in numerous biological activities including lipid raft stabilization, protein apical trafficking, cell adhesion, wound healing, intestinal inflammation, and host defense.
Tags：Galectin-4
Descriptions：C-X-C motif chemokine 3 (CXCL3) also named Growth-regulated oncogene gamma (GROγ), which is a chemokine of the intercrine alpha family. CXCL3 is a 8 kDa protein containing 73 amino acid residues. During inflammation, CXCL3 is activated by the TNF and IL-1 which mediates the monocytes migration and adhesion by targeting the CXCR2. CXCL3 activates the JNK activity which induce the cell differentiation.
Applications：His tag
Tags：CXCL3
