Descriptions:白细胞介素-10 (IL-10),细胞因子合成抑制细胞因子(CSIF),是一种抗炎细胞因子。多种不同类型的产生IL-10,包括免疫细胞和非免疫细胞。IL-10树对突状细胞(DC)和巨噬细胞具有抑制作用,是呈递递的强效制剂,与Th1相关细胞因子IL-2和干扰素-γ(IFN-γ)的产生。IL-10也是感染期间的关键免疫调节剂,因为它能够抑制细胞因子的产生。因此,感染期间过度使用Th1和CD8+ T应答可能会受到抑制。
Tags:IL-10
Descriptions:Glucose
Tags:Glucose
Descriptions:碱性成纤维细胞生长因子 (FGF-2, bFGF) 是一种多效性细胞因子,在不同细胞和组织中发挥多种作用。FGF-2 可以刺激平滑肌细胞生长、伤口愈合和组织修复。另外,FGF-2 已被证实能够调节祖细胞向神经元和星形细胞生成的。FGF-2 涉及多种生物过程,包括细胞生长形态、组织修复、肿瘤生长和肿瘤。作为一种细胞细胞因子,FGF-2最初是从垂体中分离出来的。后来,发现它存在于多种细胞类型中,包括心肌细胞、心脏成纤维细胞、内皮细胞和平滑肌细胞。
Tags:FGF-2
Descriptions:CC基序趋化因子配体2 (CCL2) 是一个分子量为13.88 kDa的细胞因子,由125个氨基酸残基组成,又称单核细胞趋化蛋白1 (MCP1)。CCL2主要由单核细胞、巨噬细胞和树突状细胞分泌。它调节多种生物学功能,例如单核细胞、记忆T细胞、嗜酸性粒细胞和树突状细胞的募集,辅助性T细胞的外渗,对TNFα和IFNγ的应答,以及血管生成。此外,CCL2与CCR4结合后,可启动炎症反应中的白细胞迁移。
Tags:CCL2
Descriptions:IL-5 is a 45-60 kDa homodimer cytokine that functions principally in the eosinophil arm of the Th2 response. It is a member of the helical bundle family of cytokines, along with IL-3, IL-4, and granulocyte-macrophage colony-stimulating factor (GM-CSF).
Tags:IL-5
Descriptions:Interleukin-1 alpha (IL1 alpha or IL1α) is a member of the interleukin-1 cytokine family, found constitutively present in epithelial layers of the entire gastrointestinal tract, lung, liver, kidney, endothelial cells, and astrocytes. The synthesized IL-1 alpha is a 31 kDa inactive precursor and can be cleaved by intracellular caspase-1 or extracellular proteases to generate the bioactive 17 kDa form and the 16 kDa N-terminal cleavage product. Both precursor and mature IL-1 alpha protein bind to the IL-1 receptor (IL-1R), initiating a cascade of inflammatory cytokines and chemokines production such as IL-6, IL-8, and TNF, in response to viral and bacterial pathogens conditions. IL-1 alpha plays a central role in immune-surveillance mechanisms, stimulating macrophages, neutrophils, and CD8+ T cells activity.
Applications:His tag
Tags:IL-1α
Descriptions:MPO
Tags:MPO
Descriptions:Interleukin 24 (IL-24) predicts a molecular mass of 18.2 kDa, is a cytokine belonging to the IL-10 family of cytokines that signals through IL-20R1 /IL-20R2 and IL-22R1 /IL-20R2. Its normal physiological role relates to wound healing, protection against diseases caused by bacteria.
Tags:IL-24
Descriptions:β-神经生长因子 (Beta-NGF) 是一种分子量为 27 kDa 的细胞因子,含有 241 个氨基酸残基。Beta-NGF 属于神经营养因子家族,具有神经营养因子的功能。它由 α、β、γ 亚基组成,其中 β 亚基与其生物活性相关。Beta-NGF 与 p75 神经营养因子受体和 Trk 受体结合,其功能分别与细胞死亡和存活相关。
Tags:β-NGF
Descriptions:SSS
Tags:SSS