Descriptions：Bone morphogenetic protein -4 (BMP-4) is one of nine structurally related BMP's, belonging to transforming growth factor-β (TGF-β) superfamily, which secretes proteins. Mature BMP-4 is a dimer that binds to a multimeric transmembrane receptor with serine/threonine kinase activity. BMP-4 treatment promoted the proliferation of HCC cells and induced autophagy. Mechanism study shows that autophagy induced by BMP-4 is mediated by activating JNK1/Bcl2 pathway. JNK1 inhibitor and JNK1 knockout can weaken BMP-4-induced autophagy and eliminate BMP-4-promoted HCC cell growth. BMP-4 promotes the proliferation of HCC through autophagy activation of JNK1/Bcl-2 signaling.
Tags：BMP-4
Descriptions：Glutaminase (GLS)
Tags：Glutaminase (GLS)
Descriptions：Glucoamylase
Tags：Glucoamylase
Descriptions：FBP
Tags：FBP
Descriptions：白细胞介素-10 (IL-10)，又称人类细胞因子合成抑制因子 (CSIF)，是一种抗炎细胞因子。许多不同类型的细胞都能产生 IL-10，包括免疫细胞和非免疫细胞。IL-10 对树突状细胞 (DC) 和巨噬细胞具有抑制作用，是抗原呈递的强效抑制剂，并限制 Th1 相关细胞因子 IL-2 和干扰素-γ (IFN-γ) 的产生。IL-10 也是感染期间的关键免疫调节剂，因为它能够抑制炎症细胞因子的产生。因此，感染期间过度的 Th1 和 CD8+ T 细胞应答可能会受到抑制。
Tags：IL-10
Descriptions：Active matrix metalloproteinase-7 (Active MMP-7) is a 20.07 kDa matrix metalloproteinases with 180 amino acid residues. MMP-7 restricted production by normal mucosal and exocrine gland epithelial cells, as well as by carcinoma cells. Functionally, it involved breakdown of extracellular matrix (casein, gelatins of types I, III, IV, and V, and fibronectin) in normal physiological processes and disease processes. MMP-7 is contributed to early tumor development during carcinogenesis.
Tags：MMP7 (active)
Descriptions：Malic enzyme (ME) is widely present in the cytoplasm of microorganisms, cultured cells, animals, and plants, especially with high activity in plant tissues. ME catalyzes the reversible oxidation decarboxylation of malic acid, producing pyruvate and CO2, as well as the reduction reaction accompanied by NAD(P)+, which is a key enzyme in malic acid metabolism.
Descriptions：Insulin like Growth Factors 1 (IGF-I) is a 7.79 kDa member of the Insulin-like Growth Factors with 71 amino acid residues. IGF-I is mainly expressed from liver, adipose tissue, Endometrial stromal cells, Leydig cells, and can be isolated from plasma. IGF-I mediating the protein anabolic and promoting effect of pituitary growth hormone. IGF-I also affects metabolism of glycogen, DNA synthesis and glucose uptake via binding to IGF-I receptor.
Tags：IGF-I
Descriptions：Human Oxytocin Receptor (OXTR) ELISA Kit employs a two-site sandwich ELISA to quantitate OXTR in samples.
Reactivity：Human
Applications：ELISA
Tags：OXTR
Descriptions：Total Sulfhydryl Group
