Descriptions：Hydroxyproline (HYP)

Tags：Hydroxyproline (HYP)

Descriptions：神经生长因子 (NGF) 对交感神经和感觉神经元系统的发育和维持至关重要。NGF 已被证实是由 α、β 和 γ 三个多肽亚基组成的复合物。其中，β 亚基（称为 β-NGF）是一个分子量为 26.9 kDa 的蛋白质，含有 241 个残基，参与神经元的存活和分化。此外，β-NGF 还可作为 TRKA 受体的配体，而 TRKA 受体对于痛觉和温度感知神经元的分化和发育至关重要。

Tags：β-NGF

Descriptions：Human Oxytocin Receptor (OXTR) ELISA Kit employs a two-site sandwich ELISA to quantitate OXTR in samples.

Reactivity：Human

Applications：ELISA

Tags：OXTR

Descriptions：Macrophage Colony Stimulating Factor (M-CSF) is a 18.54 kDa member of hematopoietic Growth Factors with 159 amino acid residues. M-CSF produced by osteoblasts and osteoblast precursors. M-CSF stimulates the growth and differentiation of the monocyte lineage, and promotes the survival, proliferation, and functions of mature monocytes/macrophages.

Tags：M-CSF

Descriptions：IL17A

Applications：No tag

Tags：IL17A

Descriptions：Glutamate Decarboxylase (GAD)

Tags：Glutamate Decarboxylase (GAD)

Descriptions：白细胞介素-10 (IL-10)，又称人类细胞因子合成抑制因子 (CSIF)，是一种抗炎细胞因子。许多不同类型的细胞都能产生 IL-10，包括免疫细胞和非免疫细胞。IL-10 对树突状细胞 (DC) 和巨噬细胞具有抑制作用，是抗原呈递的强效抑制剂，并限制 Th1 相关细胞因子 IL-2 和干扰素-γ (IFN-γ) 的产生。IL-10 也是感染期间的关键免疫调节剂，因为它能够抑制炎症细胞因子的产生。因此，感染期间过度的 Th1 和 CD8+ T 细胞应答可能会受到抑制。

Tags：IL-10

Descriptions：细胞因子干扰素γ（IFN-γ）能够保护细胞免受病毒感染，属于干扰素家族。大量研究表明，抗原触发的细胞类型包括T细胞、幼稚CD4+T细胞、巨噬细胞、树突状细胞和B细胞。IFN-γ在触发巨噬细胞对抗多种微生物靶点方面发挥重要作用，并且是一种与抗增殖、促凋亡和抗肿瘤机制相关的多效性分子。由于IFN-γ被认为是免疫的主要效应因子，因此已被用于治疗多种疾病。

Tags：IFN-γ

Descriptions：Insulin like Growth Factors 1 (IGF-I) is a 7.79 kDa member of the Insulin-like Growth Factors with 71 amino acid residues. IGF-I is mainly expressed from liver, adipose tissue, Endometrial stromal cells, Leydig cells, and can be isolated from plasma. IGF-I mediating the protein anabolic and promoting effect of pituitary growth hormone. IGF-I also affects metabolism of glycogen, DNA synthesis and glucose uptake via binding to IGF-I receptor.

Tags：IGF-I

Descriptions：Bone morphogenetic protein -4 (BMP-4) is one of nine structurally related BMP's, belonging to transforming growth factor-β (TGF-β) superfamily, which secretes proteins. Mature BMP-4 is a dimer that binds to a multimeric transmembrane receptor with serine/threonine kinase activity. BMP-4 treatment promoted the proliferation of HCC cells and induced autophagy. Mechanism study shows that autophagy induced by BMP-4 is mediated by activating JNK1/Bcl2 pathway. JNK1 inhibitor and JNK1 knockout can weaken BMP-4-induced autophagy and eliminate BMP-4-promoted HCC cell growth. BMP-4 promotes the proliferation of HCC through autophagy activation of JNK1/Bcl-2 signaling.

Tags：BMP-4