Descriptions:血管内皮生长因子165(VEGF165)是一种强效的生长和血管生成细胞因子,属于VEGF家族,包括VEGF-A、VEGF-B、VEGF-C、VEGF-D、VEGF-E和PIGF。人VEGF165是一种丰富的糖基化细胞因子,由两条相同的165个氨基酸链组成。人VEGF165在胚胎血管生成、血管生成和神经发生中发挥重要作用。
Tags:VEGF165
Descriptions:DNA Ladder
Tags:DNA Ladder
Descriptions:白细胞介素17A(IL-17A)预测浓度为35 kDa,其编码基因IL17A是由活化T细胞产生的促炎细胞因子。该细胞因子调节剂NF-κB和丝裂原活化蛋白抑制剂的活性。
Tags:IL-17
Descriptions:Methylcitrate Synthase (MCS)
Descriptions:核因子κB受体激活(RANK)配体(RANKL)是TNF细胞因子超家族中的镰基分裂,具有外结构域的II型跨膜蛋白。RANKL是一个核苷酸为19.8 kDa的蛋白质,含有3317个残基,在T细胞和显着T细胞的器官(如表达胸腺和肝脏)中高。RANKL-RANK(RANKL受体)在骨代谢、胶原蛋白和免疫系统中发挥重要作用。
Tags:RANKL
Descriptions:Hepatic Lipase (HL)
Tags:Hepatic Lipase (HL)
Descriptions:神经生长因子 (NGF) 对交感神经和感觉神经元系统的发育和维持至关重要。NGF 已被证实是由 α、β 和 γ 三个多肽亚基组成的复合物。其中,β 亚基(称为 β-NGF)是一个分子量为 26.9 kDa 的蛋白质,含有 241 个残基,参与神经元的存活和分化。此外,β-NGF 还可作为 TRKA 受体的配体,而 TRKA 受体对于痛觉和温度感知神经元的分化和发育至关重要。
Tags:β-NGF
Descriptions:Bone morphogenetic protein -4 (BMP-4) is one of nine structurally related BMP's, belonging to transforming growth factor-β (TGF-β) superfamily, which secretes proteins. Mature BMP-4 is a dimer that binds to a multimeric transmembrane receptor with serine/threonine kinase activity. BMP-4 treatment promoted the proliferation of HCC cells and induced autophagy. Mechanism study shows that autophagy induced by BMP-4 is mediated by activating JNK1/Bcl2 pathway. JNK1 inhibitor and JNK1 knockout can weaken BMP-4-induced autophagy and eliminate BMP-4-promoted HCC cell growth. BMP-4 promotes the proliferation of HCC through autophagy activation of JNK1/Bcl-2 signaling.
Tags:BMP-4
Descriptions:细胞因子干扰素γ(IFN-γ)能够保护细胞免受病毒感染,属于干扰素家族。大量研究表明,抗原触发的细胞类型包括T细胞、幼稚CD4+T细胞、巨噬细胞、树突状细胞和B细胞。IFN-γ在触发巨噬细胞对抗多种微生物靶点方面发挥重要作用,并且是一种与抗增殖、促凋亡和抗肿瘤机制相关的多效性分子。由于IFN-γ被认为是免疫的主要效应因子,因此已被用于治疗多种疾病。
Tags:IFN-γ
Descriptions:Mouse FGF1, which is produced by multiple cell types, stimulates the proliferation of all cells of mesodermal origin and many cells of neuroectodermal, ectodermal, and endodermal origin. It plays a number of roles in development, regeneration, and angiogenesis. It is released extracellularly as a disulfide-linked homodimer and is stored in complex with extracellular heparan sulfate. Intracellular Mouse FGF1 functions as a survival factor by inhibiting p53 activity and proapoptotic signalin.
Tags:FGF1