Descriptions：白细胞介素17A（IL-17A）预测浓度为35 kDa，其编码基因IL17A是由活化T细胞产生的促炎细胞因子。该细胞因子调节剂NF-κB和丝裂原活化蛋白抑制剂的活性。
Tags：IL-17
Descriptions：核因子κB受体激活（RANK）配体（RANKL）是TNF细胞因子超家族中的镰基分裂，具有外结构域的II型跨膜蛋白。RANKL是一个核苷酸为19.8 kDa的蛋白质，含有3317个残基，在T细胞和显着T细胞的器官（如表达胸腺和肝脏）中高。RANKL-RANK（RANKL受体）在骨代谢、胶原蛋白和免疫系统中发挥重要作用。
Tags：RANKL
Descriptions：神经生长因子 (NGF) 对交感神经和感觉神经元系统的发育和维持至关重要。NGF 已被证实是由 α、β 和 γ 三个多肽亚基组成的复合物。其中，β 亚基（称为 β-NGF）是一个分子量为 26.9 kDa 的蛋白质，含有 241 个残基，参与神经元的存活和分化。此外，β-NGF 还可作为 TRKA 受体的配体，而 TRKA 受体对于痛觉和温度感知神经元的分化和发育至关重要。
Tags：β-NGF
Descriptions：细胞因子干扰素γ（IFN-γ）能够保护细胞免受病毒感染，属于干扰素家族。大量研究表明，抗原触发的细胞类型包括T细胞、幼稚CD4+T细胞、巨噬细胞、树突状细胞和B细胞。IFN-γ在触发巨噬细胞对抗多种微生物靶点方面发挥重要作用，并且是一种与抗增殖、促凋亡和抗肿瘤机制相关的多效性分子。由于IFN-γ被认为是免疫的主要效应因子，因此已被用于治疗多种疾病。
Tags：IFN-γ
Descriptions：Mouse FGF1, which is produced by multiple cell types, stimulates the proliferation of all cells of mesodermal origin and many cells of neuroectodermal, ectodermal, and endodermal origin. It plays a number of roles in development, regeneration, and angiogenesis. It is released extracellularly as a disulfide-linked homodimer and is stored in complex with extracellular heparan sulfate. Intracellular Mouse FGF1 functions as a survival factor by inhibiting p53 activity and proapoptotic signalin.
Tags：FGF1
Descriptions：Bone morphogenetic protein -4 (BMP-4) is one of nine structurally related BMP's, belonging to transforming growth factor-β (TGF-β) superfamily, which secretes proteins. Mature BMP-4 is a dimer that binds to a multimeric transmembrane receptor with serine/threonine kinase activity. BMP-4 treatment promoted the proliferation of HCC cells and induced autophagy. Mechanism study shows that autophagy induced by BMP-4 is mediated by activating JNK1/Bcl2 pathway. JNK1 inhibitor and JNK1 knockout can weaken BMP-4-induced autophagy and eliminate BMP-4-promoted HCC cell growth. BMP-4 promotes the proliferation of HCC through autophagy activation of JNK1/Bcl-2 signaling.
Tags：BMP-4
Descriptions：FBP
Tags：FBP
Descriptions：白细胞介素-10 (IL-10)，又称人类细胞因子合成抑制因子 (CSIF)，是一种抗炎细胞因子。许多不同类型的细胞都能产生 IL-10，包括免疫细胞和非免疫细胞。IL-10 对树突状细胞 (DC) 和巨噬细胞具有抑制作用，是抗原呈递的强效抑制剂，并限制 Th1 相关细胞因子 IL-2 和干扰素-γ (IFN-γ) 的产生。IL-10 也是感染期间的关键免疫调节剂，因为它能够抑制炎症细胞因子的产生。因此，感染期间过度的 Th1 和 CD8+ T 细胞应答可能会受到抑制。
Tags：IL-10
Descriptions：Active matrix metalloproteinase-7 (Active MMP-7) is a 20.07 kDa matrix metalloproteinases with 180 amino acid residues. MMP-7 restricted production by normal mucosal and exocrine gland epithelial cells, as well as by carcinoma cells. Functionally, it involved breakdown of extracellular matrix (casein, gelatins of types I, III, IV, and V, and fibronectin) in normal physiological processes and disease processes. MMP-7 is contributed to early tumor development during carcinogenesis.
Tags：MMP7 (active)
