| Product name | Z280B Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from part region of human Z280B protein |
| Host | Rabbit |
| Reactivity | Human |
| Applications | WB,ELISA |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000;ELISA 1:5000-20000 |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Alternative | Zinc finger protein 280B; 5'OY11.1; Suppressor of hairy wing homolog 2; Zinc finger protein 279; Zinc finger protein 632 |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Molecular weight | 59kD |
| Storage buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | The protein encoded by ZNF280B (Zinc Finger Protein 280B) is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. ZNF280B is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for ZNF280B, but only one of them is protein-coding. |
| Gene ID | 140883 |
| Alternative | Zinc finger protein 280B; 5'OY11.1; Suppressor of hairy wing homolog 2; Zinc finger protein 279; Zinc finger protein 632 |
| Others | The antibody detects endogenous levels of Z280B protein |
| Accession | Q86YH2 |
| Observed Band(KD) | 59 |
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