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USP50 Polyclonal Antibody

USP50 Polyclonal Antibody

Views(400) Publications(0) Catalog no(ABP52682)
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Specification

Product name USP50 Polyclonal Antibody
Immunogen Synthesized peptide derived from the C-terminal region of human USP50 at AA range: 220-300
Host Rabbit
Reactivity Human, Mouse
Applications ELISA, IHC-P, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:20000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative USP50; Inactive ubiquitin carboxyl-terminal hydrolase 50; Inactive ubiquitin-specific peptidase 50

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. USP50 (ubiquitin specific peptidase 50) is a 339 amino acid protein that belongs to the peptidase C19 family of proteins. Weakly expressed in a few tissues, USP50 contains all of the active residues necessary to function as a deubiquitinating enzyme, but it appears to be catalytically inactive. The gene ecoding USP50 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.
Gene ID 373509
Alternative USP50; Inactive ubiquitin carboxyl-terminal hydrolase 50; Inactive ubiquitin-specific peptidase 50
Others USP50 Polyclonal Antibody detects endogenous levels of USP50 protein.
Accession Q70EL3
Observed Band(KD) 38

Image & description

Fig. Western Blot analysis of various cells using USP50 Polyclonal Antibody. Secondary antibody (catalog#: A21020) was diluted at 1:20000.

Fig. Western Blot analysis of various cells using USP50 Polyclonal Antibody. Secondary antibody (catalog#: A21020) was diluted at 1:20000.

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