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Rb (phospho Ser249) Polyclonal Antibody

Rb (phospho Ser249) Polyclonal Antibody

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Product name Rb (phospho Ser249) Polyclonal Antibody
Immunogen Synthesized peptide derived from human Rb around the phosphorylation site of S249
Host Rabbit
Reactivity Human, Mouse, Rat
Applications ELISA, IF
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IF (1:200-1:1000), ELISA (1:5000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background The protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Gene ID 5925
Alternative RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110
Others Phospho-Rb (S249) Polyclonal Antibody detects endogenous levels of Rb protein only when phosphorylated at S249.
Accession P06400

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