| Product name | MYSM1 Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from the Internal region of human MYSM1 at AA range: 490-570 |
| Host | Rabbit |
| Reactivity | Human |
| Applications | ELISA, IHC-P, WB |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:40000). Not yet tested in other applications. |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Alternative | MYSM1; KIAA1915; Histone H2A deubiquitinase MYSM1; 2A-DUB; Myb-like; SWIRM and MPN domain-containing protein 1 |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Storage buffer | PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | MYSM1 (Myb Like, SWIRM And MPN Domains 1) is a Protein Coding gene. Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. Diseases associated with MYSM1 include hemorrhagic cystitis. Gene Ontology (GO) annotations related to this gene include chromatin binding and protein complex binding. An important paralog of this gene is MPND. |
| Gene ID | 114803 |
| Alternative | MYSM1; KIAA1915; Histone H2A deubiquitinase MYSM1; 2A-DUB; Myb-like; SWIRM and MPN domain-containing protein 1 |
| Others | MYSM1 Polyclonal Antibody detects endogenous levels of MYSM1 protein. |
| Accession | Q5VVJ2 |
| Observed Band(KD) | 95 |
Fig.1. Western Blot analysis of various cells using MYSM1 Polyclonal Antibody diluted at 1:2000.
Fig.2. Western Blot analysis of MCF7 cells using MYSM1 Polyclonal Antibody diluted at 1:2000.
Fig.3. Western blot analysis of hela lysate using MYSM1 antibody. Antibody was diluted at 1:2000.
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