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MOR-1 (phospho Ser375) Polyclonal Antibody

MOR-1 (phospho Ser375) Polyclonal Antibody

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Specification

Product name MOR-1 (phospho Ser375) Polyclonal Antibody
Immunogen Synthesized peptide derived from human MOR-1 around the phosphorylation site of S375
Host Rabbit
Reactivity Human, Mouse, Rat
Applications ELISA, IHC-P, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:20000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative OPRM1; MOR1; Mu-type opioid receptor; M-OR-1; MOR-1; Mu opiate receptor; Mu opioid receptor; MOP; hMOP

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background OPRM1 encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains.
Gene ID 4988
Alternative OPRM1; MOR1; Mu-type opioid receptor; M-OR-1; MOR-1; Mu opiate receptor; Mu opioid receptor; MOP; hMOP
Others Phospho-MOR-1 (S375) Polyclonal Antibody detects endogenous levels of MOR-1 protein only when phosphorylated at S375.
Accession P35372
Observed Band(KD) 45

Image & description

Fig.1. Western Blot analysis of various cells using Phospho-MOR-1 (S375) Polyclonal Antibody.

Fig.1. Western Blot analysis of various cells using Phospho-MOR-1 (S375) Polyclonal Antibody.

Fig.2. Western Blot analysis of Lovo cells using Phospho-MOR-1 (S375) Polyclonal Antibody.

Fig.2. Western Blot analysis of Lovo cells using Phospho-MOR-1 (S375) Polyclonal Antibody.

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