| Product name | Human NT-3 Protein |
| Sequence | Amino acid sequence derived from the processed form of Human NT-3 (P20783-1) (Tyr139-Thr257) was expressed and purified |
| Protein length | The recombinant Human NT-3 consists of 119 amino acids with 6 ×His tag at N- terminus and has a predicted molecular mass of 16 kDa. |
| Preparation method | E. coli |
| Purity | > 96% as determined by SDS-PAGE |
| Alternative | HDNF ; NGF-2 ; NGF2 ; NT-3; NT3 |
| Formulation | Lyophilized from sterile 20 mM Tris 10% Glycerol, pH 8.0. |
| Features & Benefits | Endotoxin: <0.1 EU per μg of the protein as determined by the LAL method. |
| Molecular weight | 16 kDa |
| Usage notes | Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human NT-3 protein using the buffer we provided not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| Storage instructions | Lyophilized Human NT-3 protein product should be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
| Shipping | The product is shipped at ambient temperature. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | Human Neurotrophin-3 (NT-3) is a member of the neurotrophin family, that controls the survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. NT-3 is a key mediator of neuronal development during the early neurogenic period. NT-3 is a novel target gene of POU3F2 and that the POU3F2/NT-3 pathway plays a role in the process of neuronal differentiation. NT-3 is capable of activating TrkB to induce anoikis resistance, and show that NT-3 is also a direct target of miR-200c. NT-3 is broadly expressed in the ovary, spleen, and other tissues. Diseases associated with NT-3 include Hypochondriasis and Demyelinating Disease. |
| Gene ID | 4908 |
| Alternative | HDNF ; NGF-2 ; NGF2 ; NT-3; NT3 |
| Accession | P20783 |
Fig.Human Human NT-3 Protein.
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