| Product name | Human LIF Protein |
| Sequence | Amino acid sequence derived from Human LIF (Ser23-Phe202) (P15018-1) was expressed. |
| Applications | No tag |
| Applications notes | Human |
| Activity | Measured by its ability to induce proliferation in TF-1 cells. The ED50 for this effect is 1.079 ng/mL. |
| Protein length | The recombinant Human LIF Protein consists of 180 amino acids and predicts a molecular mass of 22.1 kDa. |
| Preparation method | E.coli |
| Purity | > 98 % as determined by SDS-PAGE |
| Molecular Formula | 22.1 kDa |
| Alternative | Differentiation-stimulating factor, D factor, Melanoma-derived LPL inhibitor (MLPLI), Interleukin 6 family cytokine |
| Formulation | Lyophilized from sterile 20mM Tris，50mM NaCl, pH 8.0. |
| Features & Benefits | < 0.1 EU per μg of the protein as determined by the LAL method. |
| Molecular weight | 22.1 kDa |
| Usage notes | Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized protein using the buffer we provided not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. |
| Storage instructions | Lyophilized protein product should be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | Leukemia Inhibitory Factor (LIF) belongs to the IL-6 superfamily of cytokines. LIF is expressed in a number of tissues and cell types. The LIF receptor is a heterodimer comprised of LIF-R (gp190) and gp130, a common signal transducer for IL-6-type cytokines. Depending on cell type and context, LIF/LIF-R can activate Erk, PI3K, and Jak1/Stat1/3 pathways. LIF has a diverse array of biological activities. Murine embryonic stem cells are dependent on LIF for pluripotency and self-renewal in vitro. Exercise- induced LIF secretion in muscle induces myoblast proliferation, suggesting that LIF may play a role in exercise-induced muscle hypertrophy. LIF also negatively regulates Th2 and Th17 cell differentiation. |
| Gene ID | 3976 |
| Alternative | Differentiation-stimulating factor, D factor, Melanoma-derived LPL inhibitor (MLPLI), Interleukin 6 family cytokine |
| Accession | P15018-1 |
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1.The species of antibody reactivity should be the sample species that can be matched normally after Abbkine R&D experts have passed strict scientific verification. If your sample is not within the range of reactivity, in order to improve the efficiency and results of your experiment, it is not suggested to try other species. Otherwise, it may lead to sample mismatch and affect the effect of your experiment.
2.Please aliquot the antibody received as soon as possible and store it at -20℃, avoid repeated freezing and thawing, and use it within one year.
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