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Human IL-4 protein

Human IL-4 protein

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Specification

Product name Human IL-4 protein
Sequence Amino acid sequence derived from Human IL-4 protein isoform (P05112,Met 1-Ser153) was expressed.
Activity Testing in progress.
Protein length The recombinant Human IL-4 protein consists of 133 amino acids and has a predicted molecular mass of 15.4 kDa. The apparent molecular mass of the Human IL-4 protein is approximately 18 kDa in SDS-PAGE under reducing conditions.
Preparation method HEK293 Cells
Purity ≥95 % as determined by SDS-PAGE
Alternative IL4; IL-4; IL-4B_cell stimulatory factor 1;B cell growth factor 1; BCGF1; BCGF-1; interleukin 4; binetrakin; BCDF; B-cell stimulatory factor 1; BSF1; BSF-1; IL4E12; interleukin-4; Lymphocyte stimulatory factor 1; MGC79402; pitrakinra

Product Properties

Formulation Lyophilized from sterile PBS, pH 7.4.
Molecular weight 15.4 kDa
Usage notes Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human IL-4 protein using the buffer we provided not less than 100 µg/mL, which can then be further diluted to other aqueous solutions.
Storage instructions Lyophilized Human IL-4 proteinshould be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.129% HSA or BSA). Please prevent freeze-thaw cycles.
Shipping The product is shipped at ambient temperature.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background Interleukin-4(IL-4), an anti-inflammatory cytokine, plays significant role in pathogenesis of various diseases such as asthma, tumors, and HIV infections. IL-4 is firstly identified as a T cell-derived growth factor for B cells. IL-4 can mediate important pro-inflammatory functions in asthma, including T helper cell type 2 lymphocyte differentiation, induction of IgE production, up-regulation of IgE receptors, expression of vascular cell-adhesion molecule 1, promotion of eosinophil transmigration into the lungs, inhibition of T-lymphocyte apoptosis, and mucus hypersecretion. The role of IL-4 in the pathogenesis of asthma is supported by identification of polymorphisms linked to asthma in the IL-4 gene promoter and proteins involved in IL-4 signaling.
Gene ID 3565
Alternative IL4; IL-4; IL-4B_cell stimulatory factor 1;B cell growth factor 1; BCGF1; BCGF-1; interleukin 4; binetrakin; BCDF; B-cell stimulatory factor 1; BSF1; BSF-1; IL4E12; interleukin-4; Lymphocyte stimulatory factor 1; MGC79402; pitrakinra
Accession P05112

Image & description

Fig.SDS-PAGE analysis of Human IL-4 protein.

Fig.SDS-PAGE analysis of Human IL-4 protein.

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