Product Information

• Product name

  DRAK2 Polyclonal Antibody

• Immunogen

  Synthesized peptide derived from the Internal region of human DRAK2 at AA range: 220-300

• Host

  Rabbit

• Reactivity

  Human, Mouse, Rat

• Applications

  ELISA, IHC-P, WB

• Application notes

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:40000). Not yet tested in other applications.

• Clonality

  Polyclonal

• Isotype

  Rabbit IgG

• Purification

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Fig.1. Western Blot analysis of various cells using DRAK2 Polyclonal Antibody.

Fig.2. Western Blot analysis of brain cells using DRAK2 Polyclonal Antibody.

Product Properties

• Formulation

  Liquid solution

• Concentration

  1 mg/ml

• Storage buffer

  PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.

• Storage instructions

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Shipping

  Gel pack with blue ice.

• Precautions

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

• Background

  DAP (death associated protein) kinase and ZIP kinase are members of a novel protein kinase family, the members of which have the capacity to mediate apoptosis through their catalytic activities. DAP kinase contains a "death domain" and has been shown to mediate gamma interferon-induced apoptosis. The introduction of DAP kinase into highly metastatic carcinoma clones lacking DAP kinase expression was shown to result in the suppression of metastasis, thus linking suppression of apoptosis to metastasis. ZIP kinase contains a leucine zipper domain, which is necessary for homodimerization and for interaction with other leucine zipper proteins. ZIP kinase dimerizes with ATF-4, an ATF/CREB transcription factor family member that contains a leucine zipper. DRAK1 (DAP kinase-related apoptosis-inducing protein kinase 1) and DRAK2 are DAP kinase related proteins. DRAK1 and DRAK2 are localized to the nucleus, and overexpression of both DRAK proteins in NIH/3T3 cells induces morphological changes associated with apoptosis.

• Gene ID

  9262

• Alternative names

  STK17B; DRAK2; Serine/threonine-protein kinase 17B; DAP kinase-related apoptosis-inducing protein kinase 2

• Others

  DRAK2 Polyclonal Antibody detects endogenous levels of DRAK2 protein.

• Accession

  O94768