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Dok-2 (phospho Tyr299) Polyclonal Antibody

Dok-2 (phospho Tyr299) Polyclonal Antibody

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Specification

Product name Dok-2 (phospho Tyr299) Polyclonal Antibody
Immunogen Synthesized peptide derived from human Dok-2 around the phosphorylation site of Y299
Host Rabbit
Reactivity Human, Monkey, Mouse
Applications ELISA, IF, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IF (1:200-1:1000), ELISA (1:20000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative DOK2; Docking protein 2; Downstream of tyrosine kinase 2; p56(dok-2)

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background Docking protein 2 encoded by DOK2 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 2 binds p120 (RasGAP) from CML cells.
Gene ID 9046
Alternative DOK2; Docking protein 2; Downstream of tyrosine kinase 2; p56(dok-2)
Others Phospho-Dok-2 (Y299) Polyclonal Antibody detects endogenous levels of Dok-2 protein only when phosphorylated at Y299.
Accession O60496
Observed Band(KD) 48

Image & description

Fig. Western Blot analysis of various cells using Phospho-Dok-2 (Y299) Polyclonal Antibody.

Fig. Western Blot analysis of various cells using Phospho-Dok-2 (Y299) Polyclonal Antibody.

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