Login Register
English
0

Cart

$ 0

Cyclin A1 Polyclonal Antibody

Cyclin A1 Polyclonal Antibody

Views(363) Publications(0) Catalog no(ABP51080)
Datasheet Print Share Email Share
  • Specification
  • FAQ
  • Publications(0)
  • Comments(0)

Specification

Product name Cyclin A1 Polyclonal Antibody
Immunogen Synthesized peptide derived from the C-terminal region of human Cyclin A1 at AA range: 380-460
Host Rabbit
Reactivity Human, Mouse, Rat
Applications ELISA, IHC-P, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:40000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative CCNA1; Cyclin-A1

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background Cyclin A1 encoded by CCNA1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for CCNA1.
Gene ID 8900
Alternative CCNA1; Cyclin-A1
Others Cyclin A1 Polyclonal Antibody detects endogenous levels of Cyclin A1 protein.
Accession P78396
Observed Band(KD) 52

Image & description

Fig.1. Western Blot analysis of various cells using Cyclin A1 Polyclonal Antibody diluted at 1:2000.

Fig.1. Western Blot analysis of various cells using Cyclin A1 Polyclonal Antibody diluted at 1:2000.

Fig.2. Western Blot analysis of HeLa cells using Cyclin A1 Polyclonal Antibody diluted at 1:2000.

Fig.2. Western Blot analysis of HeLa cells using Cyclin A1 Polyclonal Antibody diluted at 1:2000.

This product has been cited in0publications

Reviews

There are no reviews yet.

Be the first to review “Cyclin A1 Polyclonal Antibody”